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	Provedor de dados BJPS (1) Autor Gürten,Berna (1) Malta,Seyda (1) Sezer,Ali Demir (1) Yenigül,Elçin (1) Palavra-chave Calorimetry. (1) Chromatography (1) Cyclodextrins (1) Temozolomide/solubility/complexation (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Complexation and enhancement of temozolomide solubility with cyclodextrins BJPS Gürten,Berna; Yenigül,Elçin; Sezer,Ali Demir; Malta,Seyda. ABSTRACT Temozolomide is a poorly soluble anti-cancer drug used in the treatment of some brain cancers. Following literature reports about the enhancement of solubility and stability for these kinds of drugs upon complexation with cyclodextrins, we aimed to form an inclusion complex between temozolomide and the different types of cyclodextrins (CDs) to enhance its solubility. In this study, three different cyclodextrins (β -CD, hydroxyl-β-CD and γ-CD) were used, and changes in solubility was measured by UV-Vis Spectroscopy and HPLC. Morphological changes upon complexation were shown by the Scanning Electron Microscope (SEM), and weight loss profiles with respect to temperatures which were unique to the compounds were shown by Thermogravimetric Analysis.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Temozolomide/solubility/complexation; Cyclodextrins; Chromatography; Calorimetry.. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200606 Registros recuperados: 1 Primeira ... 1 ... Última

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