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Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy Arq. Bras. Med. Vet. Zootec.
Valladão,M.L.; Scarpelli,K.C.; Metze,K..
The clinical utility of a life quality score during vincristine chemotherapy of dogs with canine transmissible venereal tumor (CTVT) was investigated using 93 tumor-bearing dogs in this prospective study. At diagnosis, clinical data and the performance status were evaluated according to a modified Karnofsky score (CKS) adapted for dogs. The animals were treated with vincristine sulphate (0.025mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time until the first adverse event and death were recorded. In a pilot study, CKS revealed a high inter-observer concordance (kappa=0.735; weighted kappa=0.835). CKS permitted a detailed monitoring of adverse effects during therapy. Cox regressions showed that low performance score and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Canine transmissible venereal tumor; Vincristine; Survival; Performance score; Quality of life.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000500010
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