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| Matsumoto,Akiko; Arisaka,Hirofumi; Hosokawa,Yuki; Sakuraba,Shigeki; Sugita,Takeo; Umezawa,Nobuo; Kaku,Yuki; Yoshida,Kazu-ichi; Kuwana,Shun-ichi. |
| BACKGROUND: The antiepileptic drugs carbamazepine and gabapentin are effective in treating neuropathic pain and trigeminal neuralgia. In the present study, to analyze the effects of carbamazepine and gabapentin on neuronal excitation in the spinal trigeminal subnucleus caudalis (Sp5c) in the medulla oblongata, we recorded temporal changes in nociceptive afferent activity in the Sp5c of trigeminal nerve-attached brainstem slices of neonatal rats using a voltage-sensitive dye imaging technique. RESULTS: Electrical stimulation of the trigeminal nerve rootlet evoked changes in the fluorescence intensity of dye in the Sp5c. The optical signals were composed of two phases, a fast component with a sharp peak followed by a long-lasting component with a period of... |
| Tipo: Journal article |
Palavras-chave: Carbamazepine; Gabapentin; Rat brainstem; Spinal trigeminal nucleus; Voltage-sensitive dye imaging. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100036 |
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| Fachinelli,C.; Ahumada,M.; Fachinellizz,J.M.; Torrecilla,M.; Rodríguez-Echandía,E.L.. |
| Valproate and carbamazepine (CAR) have been proposed as adjunct alternatives for the control of aggression in psychiatric patients, although no definite conclusions have been reached. We examined the effects of these drugs on food competition offensive aggression and other behaviors in high- and low-aggression food-restricted pigeons. These were divided into pairs containing previously ranked high-aggression (N = 10 pairs) and low-aggression females (N = 10 pairs). In Experiment 1, a pigeon in each pair of high- and low-aggression subjects was treated daily with an oral dose of sodium valproate (50 mg kg-1 mL saline-1) for 15 days. The other animal received the vehicle. On days 1, 7, and 15, food competition trials (10 min) were performed 60 min after... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Valproate; Carbamazepine; Aggressive behavior; Food competition; Pigeons. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600015 |
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| Solon,Lílian Grace da Silva; Oliveira,Ana Isabel Maia de; Guerra,Gerlane Coelho Bernardo; Soares,Luiz Alberto Lira; Araújo,Aurigena Antunes de. |
| The aim of this study was to evaluate the quality of five different solid formulations of carbamazepine. The reference formulation was Tegretol® 200.00 mg (Novartis) and the others were: generic formulation of carbamazepine 200.00 mg (National Industry), similar formulation of carbamazepine 200.00 mg (National Industry), and two formulations of carbamazepine 200.00 mg acquired from two different compounding pharmacies. The latter consisted of capsules obtained in Natal, the capital city of the Brazilian State of Rio Grande do Norte. The quality of samples was evaluated through physical and physical-chemical tests, including: weight, diameter, thickness, content, dissolution, disintegration, hardness, friability and moisture. The results of friability... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carbamazepine; Medicines/quality control; Generic medicines; Similar medicines; Medicines/magistral formulation. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300014 |
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