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| 清水, 純一郎; 持田, 恭平; 岸本, 海織; 李, 奇子; 池水, 智博; 室谷, 直義; 小嶋, 靖; 山田, 一孝; SHIMIZU, Junichiro; MOCHIDA, Kyohei; KISHIMOTO, Miori; LEE, Ki-Ja; IKEMIZU, Tomohiro; MUROYA, Naoyoshi; KOJIMA, Yasushi; YAMADA, Kazutaka. |
| ハタケシメジ抽出物の白血球数調節作用を調べる目的でハタケシメジ抽出物を経口投与し，カルボプラチン投与後の骨髄抑制作用の違いを5週間にわたる経時的な血液検査により検討した。その結果，総白血球数および好中球数においてハタケシメジ抽出物投与群がプラセボ投与群に対して有意に高値を示した。このことより，カルボプラチンによる骨髄抑制に対して，ハタケシメジ抽出物が白血球数減少抑制作用を有することが確認された。 In order to elucidate the suppressive effect of Hatakeshimeji (Lyophyllum decastes Sing.) extract on leukocytopenia，the degree of carboplatin-induced myelosuppression was compared between two groups of dogs; each group was daily given Hatakeshimeji extract or only its placebo for 5 weeks，and on day 7， carboplatin，an anticancer agent，was given intravenously to all dogs. Hematological analyses revealed that the nunbers of leukocytes and neutrophils were both significantly higher in the group given Hatakeshimeji extract than in the placebo group. This indicated... |
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Palavras-chave: カルボプラチン; 犬; ハタケシメジ抽出物; Carboplatin; Dog; Hatakeshimeji extract. |
| Ano: 2008 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2929 |
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| Pereira,S.T.; Campos,C.B.; Horta,R.S.; Lavalle,G.E.; Araujo,R.B.. |
| ABSTRACT Feline Injection Site-Associated Sarcoma (FISS) is a neoplasm that implies in reduction of quality of life and overall survival in feline patients. A retrospective study of 13 cases of FISS was conducted to evaluate the efficacy of surgical treatment associated to chemotherapy with doxorubicin or carboplatin. Local recurrence occurred in all patients. Patients treated with surgery and chemotherapy presented a longer overall survival and disease-free interval when compared to those that solely received surgical treatment, although no statistical significance was observed (p= 0.3360 and 0.7506, respectively). Surgery remains as the main option for FISS treatment. Further prospective studies with larger samples are warranted to investigate the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: FISS; Doxorubicin; Carboplatin; Surgery. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000601508 |
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