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	Provedor de dados BJMBR (4) BJPS (1) Autor Almeida,A.P. (1) Azizi,Yaser (1) Boroujeni,Shakiba Nasiri (1) Chattipakorn,N. (1) Chattipakorn,S. (1) Dalvand,Parvin (1) Ferreira,A.J. (1) Kowaltowski,A.J. (1) Liu,J.C. (1) Moghimian,Maryam (1) Nazari,Afshin (1) Reis,A.M. (1) Santos,P.E.B. (1) Santos,R.A.S. (1) Savergnini,S.Q. (1) Sedighi,Mehrnoosh (1) Shinlapawittayatorn,K. (1) Zhou,X.L. (1) Mais... Palavra-chave Cardioprotection (5) Aging (1) Alternative oxidase (1) Angiogenesis (1) Cardiac fibroblast-myofibroblast transformation (1) Cardiovascular disease (1) Congenital heart disease (1) Erectile dysfunction (1) Estrogen (1) Free radicals (1) Ischemia (1) Ischemia/reperfusion (1) Langendorff technique (1) Mitochondrial permeability transition (1) Myocardial regeneration (1) Notch signaling (1) Phenylephrine (1) Phosphodiesterase inhibitor (1) Preconditioning (1) QT interval (1) Mais... Tipo do documento Info:eu-repo/semantics/article (5) Ano 2019 (1) 2014 (1) 2012 (1) 2005 (1) 2000 (1) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Effect of sildenafil citrate on the cardiovascular system BJMBR Shinlapawittayatorn,K.; Chattipakorn,S.; Chattipakorn,N.. Sildenafil citrate is a drug commonly used to manage erectile dysfunction. It is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H -pyrazolo[4,3-d]pyrimidin-5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6O4 S). It is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type 5. In late March through mid-November 1998, the US Food and Drug Administration (FDA) published a report on 130 confirmed deaths among men (mean age, 64 years) who received prescriptions for sildenafil citrate, a period during which >6 million outpatient prescriptions (representing about 50 million tablets) were dispensed. The US FDA recently reported that significant cardiovascular events, including sudden... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sildenafil citrate; Erectile dysfunction; Sudden cardiac death; Cardiovascular disease; Phosphodiesterase inhibitor; Cardioprotection. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900003 Role of Notch signaling in the mammalian heart BJMBR Zhou,X.L.; Liu,J.C.. Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical in mammalian cardiogenesis, as mutations in this signaling pathway are linked to human congenital heart disease. Furthermore, Notch signaling can repair myocardial injury by promoting myocardial regeneration, protecting ischemic myocardium, inducing angiogenesis, and negatively regulating cardiac fibroblast-myofibroblast transformation. This review provides an update on the known roles of Notch signaling in the mammalian heart. The goal is to assist in developing strategies to influence Notch signaling and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Notch signaling; Congenital heart disease; Myocardial regeneration; Cardioprotection; Angiogenesis; Cardiac fibroblast-myofibroblast transformation. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000100001 Effects of short-term administration of estradiol on reperfusion arrhythmias in rats of different ages BJMBR Savergnini,S.Q.; Reis,A.M.; Santos,R.A.S.; Santos,P.E.B.; Ferreira,A.J.; Almeida,A.P.. Little is known about age-related differences in short-term effects of estradiol on ischemia-reperfusion (I/R) insults. The present study was designed to evaluate the effects of short-term treatment with estradiol on reperfusion arrhythmias in isolated hearts of 6-7-week-old and 12-14-month-old female rats. Wistar rats were sham-operated, ovariectomized and treated with vehicle or ovariectomized and treated with 17β-estradiol (E2; 5 µg·100 g-1·day-1) for 4 days. Hearts were perfused by the Langendorff technique. Reperfusion arrhythmias, i.e., ventricular tachycardia and/or ventricular fibrillation, were induced by 15 min of left coronary artery ligation and 30 min of reperfusion. The duration and incidence of I/R arrhythmias were significantly higher in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardioprotection; Estrogen; Ischemia/reperfusion; Langendorff technique; QT interval. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200020 Alternative mitochondrial functions in cell physiopathology: beyond ATP production BJMBR Kowaltowski,A.J.. It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology. Tipo: Info:eu-repo/semantics/article Palavras-chave: Mitochondrial permeability transition; Uncoupling proteins; Alternative oxidase; Cardioprotection; Free radicals; Aging. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200014 Late cardiac perconditioning by phenylephrine in an isolated rat heart model is mediated by mitochondrial potassium channels BJPS Nazari,Afshin; Sedighi,Mehrnoosh; Dalvand,Parvin; Azizi,Yaser; Moghimian,Maryam; Boroujeni,Shakiba Nasiri. The present study was designed to investigate the effect of early and late administration of phenylephrine during ischemia against regional ischemia-reperfusion injuries in an isolated rat heart model. All animals were randomly divided into experimental groups: (I) IR (Ischemic/ reperfusion): the hearts underwent 35 min of regional ischemia followed by 60 min of reperfusion; (II) 5HD-IR-0: the hearts were perfused for 5 min with 5HD (5-hydroxydecanoate, specific mKATP channel blocker, 100 µM) at the onset of regional ischemia; (III) 5HD-IR-20: the hearts were perfused for 5 min with 5HD 20 min after regional ischemia; (IV) PE-IR-10: the hearts were perfused for 5 min with phenylephrine 10 min after regional ischemia; (V) PE-IR-30: the hearts were perfused... Tipo: Info:eu-repo/semantics/article Palavras-chave: Phenylephrine; Ischemia; Reperfusion; Preconditioning; Cardioprotection. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100561 Registros recuperados: 5 Primeira ... 1 ... Última

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