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| Ameer,O.Z.; Salman,I.M.; Siddiqui,M.J.A.; Yam,M.F.; Sriramaneni,R.N.; Sadikun,A.; Ismail,Z.; Shah,A.M.; Asmawi,M.Z.. |
| We investigated the vascular responses and the blood pressure reducing effects of different fractions obtained from the methanol extract of Loranthus ferrugineus Roxb. (F. Loranthaceae). By means of solvent-solvent extraction, L. ferrugineus methanol extract (LFME) was successively fractionated with chloroform, ethyl acetate and n-butanol. The ability of these LFME fractions to relax vascular smooth muscle against phenylephrine (PE)- and KCl-induced contractions in isolated rat aortic rings was determined. In another set of experiments, LFME fractions were tested for blood pressure lowering activity in anesthetized adult male Sprague-Dawley rats (250-300 g, 14-18 weeks). The n-butanol fraction of LFME (NBF-LFME) produced a significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Loranthus ferrugineus; N-butanol fraction; Cardiovascular effect; Aortic ring; Vasorelaxation; Terpenoid. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000200009 |
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| De Lima,ME; Borges,MH; Verano-Braga,T; Torres,FS; Montandon,GG; Cardoso,FL; Peixoto,KDBA; Cardoso-Jr,HC; Benelli,MT. |
| The search for new active drugs that can alleviate or cure different diseases is a constant challenge to researchers in the biological area and to the pharmaceutical industry. Historically, research has focused on the study of substances from plants. More recently, however, animal venoms have been attracting attention and studies have been successful in addressing treatment of accidents. Furthermore, venoms and their toxins have been considered good tools for prospecting for new active drugs or models for new therapeutic drugs. In this review, we discuss some possibilities of using different toxins, especially those from arachnid venoms, which have shown some potential application in diseases involving pain, hypertension, epilepsy and erectile dysfunction.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arachnidan toxins; Pain; Epilepsy; Cardiovascular effect; Priapism; Erectile function; Scorpion; Spider. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000100004 |
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