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	Provedor de dados BJMBR (2) Anais da ABC (AABC) (1) International Journal of Morphology (1) Autor Barione,D. F (1) Chen,S.S. (1) Cologna,A. J (1) Cui,Z.Y. (1) Franqueiro,A. G (1) Guillermo,Landi V.C. (1) Ji,C. (1) Li,H. (1) Li,Y. (1) Lizarte,F. S. N (1) Lopes,Marcela F. (1) Ma,J. (1) Martins,A. C. P (1) Novais,P. C (1) Pereira,Wânia F. (1) Peria,F. M (1) Reis,R. B (1) Ren,F. (1) Ribeiro-Gomes,Flávia L. (1) Rodrigues Jr,A. A (1) Mais... Palavra-chave Apoptosis (4) Caspase-8 (4) Bcl-2 (1) CD8 T cells (1) Cardiomyocyte (1) Caspase-3 (1) DATS (1) IFN-gamma (1) Inhibitor (1) Leishmaniasis (1) MiR-122 (1) Myocardial infarction (1) P38 MAPK (1) Penile cancer (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Journal article (1) Ano 2017 (1) 2012 (1) 2010 (1) 2008 (1) País Brazil (3) Chile (1) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Immunohistochemistry Analysis of Proteins Related with Apoptosis as Prognostic Factor inEpidermoid Carcinomaof Penis International Journal of Morphology Novais,P. C; de Paula,A. A. P; Reis,R. B; Barione,D. F; Franqueiro,A. G; Rodrigues Jr,A. A; Lizarte,F. S. N; de Carvalho,C. A. M; Tirapelli,D. P. C; Peria,F. M; Saggioro,F. P; Tucci Jr,S; Cologna,A. J; Martins,A. C. P; Tirapelli,L. F. The aim was to analyze the protein expression of apoptotic genes caspase-3, caspase-8 and bcl-2 with the immunohistochemistry technique, correlating with tumor grade (I, II and III) and with the patient survival in order to understand the basic mechanism of tumoral transformation. The immunohistochemistry reactions on 50 samples of squamous cell carcinoma were carried out with the avidin-biotin immunoperoxidase method and antigen recovery. The analyses were made using the graduation method "in crosses" (0 to 4 crosses - no stain to more than 75% of positives cells) and in categories (low, intermediate, high) of the cytoplasm immunoreactivity of the epidermoid penile carcinoma cells. It was observed a statistically significant difference when the expression... Tipo: Journal article Palavras-chave: Bcl-2; Caspase-3; Caspase-8; Penile cancer; Apoptosis. Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300043 Inhibition of caspase-8 activity reduces IFN-gamma expression by T cells from Leishmania major infection Anais da ABC (AABC) Pereira,Wânia F.; Guillermo,Landi V.C.; Ribeiro-Gomes,Flávia L.; Lopes,Marcela F.. Following infection with Leishmania major, T cell activation and apoptosis can be detected in draining lymph nodes of C57BL/6-infected mice. We investigated the mechanisms involved in apoptosis and cytokine expression following Tcellactivation. After two weeks of infection, apoptotic T cells were not detected in draining lymph nodes but activation with anti-CD3 induced apoptosis in both CD4 and CD8 T cells. Treatment with anti-FasLigand, caspase-8 or caspase- 9 inhibitors did not block activation-induced T-cell death. We also investigated whether the blockade of caspase-8 activity would affect the expression of type-1 or type-2 cytokines. At early stages of infection, both CD4 and CD8 T cells expressed IFN-gamma upon activation. Treatment with the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Caspase-8; CD8 T cells; IFN-gamma; Leishmaniasis. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100008 MicroRNA-122 regulates caspase-8 and promotes the apoptosis of mouse cardiomyocytes BJMBR Zhang,Z.W.; Li,H.; Chen,S.S.; Li,Y.; Cui,Z.Y.; Ma,J.. Cardiomyocyte apoptosis plays key roles in the pathogenesis of heart diseases such as myocardial infarction. MicroRNAs are important regulators of gene expression, which are also involved in the regulation of cardiomyocyte apoptosis. However, cardiomyocyte apoptosis regulated by microRNA (miR)-122 is largely unexplored. The aim of this study focused on the role of miR-122 in cardiomyocyte apoptosis. Cardiomyocytes were isolated from neonatal mice and primarily cultured. MiR-122 mimic and inhibitor were transfected to cardiomyocytes and verified by qRT-PCR. Cell viability and apoptosis post-transfection were assessed by MTT assay and flow cytometry, respectively. Changes in expression of caspase-8 were quantified by qRT-PCR and western blot. Results showed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiomyocyte; Apoptosis; MiR-122; Caspase-8; Myocardial infarction. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200601 Caspase-8 and p38MAPK in DATS-induced apoptosis of human CNE2 cells BJMBR Ji,C.; Ren,F.; Xu,M.. Nasopharyngeal carcinoma is a common malignancy in Southern China of uncertain etiologic origin. Diallyl trisulfide (DATS), one of the major components of garlic (Allium sativum), is highly bactericidal and fungicidal. In this study, we investigated the function of p38 mitogen-activated protein kinase (MAPK) and caspase-8 in DATS-induced apoptosis of human CNE2 cells using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], flow cytometry assay, and Western blotting. After CNE2 cells were treated with DATS (50, 100, or 150 μM) for 24 h, cell viability rates were 75.9, 63.4 and 39.6%, and apoptosis rates were 24.5, 36.9, and 62.4%, respectively. The data showed that DATS induced CNE2 cell death in a dose-dependent manner. After human CNE2... Tipo: Info:eu-repo/semantics/article Palavras-chave: DATS; P38 MAPK; Caspase-8; Inhibitor; Apoptosis. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000900003 Registros recuperados: 4 Primeira ... 1 ... Última

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