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| Registros recuperados: 19 | |
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| Amiri Chayjan, Reza; Fealekari, Mosayeb. |
| Abstract: Optimization of convective drying process of Persian shallot was investigated using dependent variables of effective moisture diffusivity (Deff), specific energy consumption (SEC), shrinkage and color changes. The central composite design (CCD) was selected for design and optimization of the process. The second-order polynomial models with transformed responses were developed from experimental data to generate three dimensional response surfaces and contour plots. Experiments were performed at air temperatures of 40°C, 55°C and 70°C, air velocities of 0.5, 1.5 and 2.5 m/s and slice thicknesses of 2, 4, and 6 mm in triplicate. Based on response surface and desirability functions, the optimum conditions for Persian shallot drying were: air... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Color; Diffusivity; Energy; Central composite design; Shrinkage. |
| Ano: 2014 |
URL: http://www.cigrjournal.org/index.php/Ejounral/article/view/2807 |
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| UBAID,MUHAMMAD; ILYAS,SADAF; MIR,SADULLAH; KHAN,ABIDA K.; RASHID,REHANA; KHAN,MUHAMMAD Z.U.; KANWAL,ZAINAB G.; NAWAZ,AHMAD; SHAH,AMNA; MURTAZA,GHULAM. |
| ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i.e. flux (Y1), lag time (Y2), diffusion coefficient (Y3), permeability coefficient (Y4), and input rate (Y5) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Central composite design; Clotrimazole; Permeability enhancer; Topical gel. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602303 |
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| Kumari,Annapurna; Mahapatra,Paramita; Banerjee,Rintu. |
| Optimization of lipase production by Enterobacter aerogenes was carried out using response surface methodology (RSM) where the statistical model was obtained by fractional factorial central composite design. The influence of various physico-chemical parameters, viz. temperature, oil concentration, inoculum volume, pH and incubation period on lipase production was examined. Optimization of physico-chemical parameters resulted 1.4- fold increase in lipase activity. The optimum levels of parameters were 34°C, oil concentration 3%, inoculum volume 7%, pH 7 and incubation time 60 h for obtaining a maximum lipase activity of 27.25 U/ml. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Central composite design; Enterobacter aerogenes; Lipase; Optimization; Parameter; Response Surface Methodology. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000600005 |
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| Zárate-Chaves,Carlos Andrés; Romero-Rodríguez,María Camila; Niño-Arias,Fabián Camilo; Robles-Camargo,Jorge; Linares-Linares,Melva; Rodríguez-Bocanegra,María Ximena; Gutiérrez-Rojas,Ivonne. |
| The present work was aimed at optimizing a culture medium for biomass production and phenolic compounds by using Ganoderma lucidum. The culture was optimized in two stages; a Plackett-Burman design was used in the first one for identifying key components in the medium and a central composite design was used in the second one for optimizing their concentration. Both responses (biomass and phenolic compounds) were simultaneously optimized by the latter methodology regarding desirability, and the optimal concentrations obtained were 50.00 g/L sucrose, 13.29 g/L yeast extract and 2.99 g/L olive oil. Maximum biomass production identified in these optimal conditions was 9.5 g/L and that for phenolic compounds was 0.0452 g/L, this being 100% better than that... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Medium optimization; Ganoderma lucidum; Plackett-Burman; Central composite design; Phenolic compounds. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000100032 |
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| Dubey,Sachin; Singh,Amit; Banerjee,Uttam C. |
| Growth and nitrilase production by recombinant Escherichia coli cells harbouring pET 21 (b) plasmid, for the expression of Pseudomonas putida nitrilase were improved using response surface methodology. Central composite design was used for obtaining ideal concentration of critical medium components which include fructose, tryptone, yeast extract and lactose. The optimal values for the concentration of fructose, tryptone, yeast extract and lactose were found to be 1.13, 2.26, 3.25 and 0.9 % (w/v), respectively. Here, fructose served as carbon source for the growth while lactose was preferably used as inducer for the expression of foreign protein. Yeast extract in the medium was used as a growth promoter while tryptone was added as a major nitrogen source.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biocatalysis; Recombinant E. coli; Nitrilase; Response surface methodology; Central composite design. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000300029 |
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| Vijayaraj,Surendran; Palei,Narahari N; Archana,Devalapalli; Lathasri,Kuppam; Rajavel,Ponnusamy. |
| Rutin is a flavonoid glycoside, mainly consists of phenolic compounds, responsible for many biological activities. The objective of the present study was to develop and validate a precise, simple, robust, rapid and reliable reverse phase high -performance liquid chromatography (RP-HPLC) technique by using Qbd approach for evaluating the rutin in nanoparticles. Central composite design (CCD) was employed for optimizing the experimental conditions of RP-HPLC method. Buffer pH, methanol content in the mobile phase composition, flow rate, and wavelength were selected as independent variables whereas retention time, peak area, and asymmetry factor was selected as dependent variables. The retention time, peak area and asymmetric factor of rutin by using... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rutin; Chitosan; Sodium aliginate; Nanoparticles; RP-HPLC; Central composite design; QbD. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100632 |
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| Zhao,Jianglin; Wang,Xiaohan; Sun,Weibo; Mou,Yan; Peng,Youliang; Zhou,Ligang. |
| Background: Berkleasmium sp. Dzf12, an endophytic fungus from Dioscorea zingiberensis, was a high producer of palmarumycin C13 with various bioactivities. In the present study, the experimental designs based on statistics were employed to evaluate and optimize the medium for palmarumycin C13 production in mycelia liquid culture of Berkleasmium sp. Dzf12. Results: Among various carbon and nitrogen sources, glucose, peptone and yeast extract were found to be the most favourable for palmarumycin C13 production based on the one-factor-at-a-time experiments. After Plackett-Burman test on the medium, glucose, peptone and yeast extract were further verified to be the most significant factors to stimulate palmarumycin C13 accumulation. These three factors (i.e.,... |
| Tipo: Journal article |
Palavras-chave: Berkleasmium sp. Dzf12; Central composite design; Endophytic fungus; Mycelia liquid culture; Palmarumycin C13; Plackett-Burman test; Response surface methodology. |
| Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582013000600016 |
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| Luo,Haiyu; Xu,Dan; Xie,Rushan; Zhang,Xuping; Wang,Jian; Xuejiao,Dong; Lai,Daowan; Zhou,Ligang; Liu,Yang. |
| Background: Hyalodendriella sp. Ponipodef12, an endophytic fungus from a poplar hybrid, was a high producer of botrallin and TMC-264 with various bioactivities. In this study, the influences of eight metal ions (i.e.,Mn2+,Na+, Mg2+,Zn2+,Cu2+,Fe2+,Fe3+ and Al3+) on botrallin and TMC-264 production in liquid culture of the endophytic fungus Hyalodendriella sp. Ponipodef12 were investigated. Results: Three most effective metal ions (Zn2+,Cu2+ and Mg2+) along with their optimum concentrations were screened. The optimum addition time and concentrations of Zn2+,Cu2+ and Mg2+ were further obtained respectively for improving botrallin and TMC-264 production. The combination effects of Zn2+,Cu2+ and Mg2+ on the production of botrallin and TMC-264 by employing... |
| Tipo: Journal article |
Palavras-chave: Combination effects; Production; Microbial biotechnology; Process biotechnology; Bioactivities; Central composite design; Response surface methodology. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582016000600002 |
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| Borguini,Renata Galhardo; Pacheco,Sidney; Chávez,Davy William Hidalgo; Couto,Giovana Almeida; Wilhelm,Allan Eduardo; Santiago,Manuela Cristina Pessanha de Araújo; Nascimento,Luzimar da Silva de Mattos do; Jesus,Monalisa Santana Coelho de; Godoy,Ronoel Luiz de Oliveira. |
| ABSTRACT: Vitamin A deficiency is the third most important micronutrient deficiency having a significant impact on public health worldwide. The aim of this study was to develop a carotenoid extraction process with edible vegetable oils, using a central composite design which, concurrently, enriches the oils with provitamin A carotenoids. The stability of carotenoids in the oil and their shelf life was also evaluated. The process also aimed to meet the Recommended Daily Intake for vitamin A (600 μg retinol equivalent for an adult) with the enriched oil. The results showed that 20 % of the vegetable matrix (dried carrot) in vegetable oil and 5 min of extraction time was an optimum combination for both soy oil (64.43 μg retinol equivalent mL−1) and olive oil... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Retinol; Food-to-food fortification; Oil shelf life; Carotenoid stability; Central composite design. |
| Ano: 2021 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162021000500901 |
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| Registros recuperados: 19 | |
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