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Registros recuperados: 13 | |
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DIAMOND,MARIAN C.. |
Before 1960, the brain was considered by scientists to be immutable, subject only to genetic control. In the early sixties, however, investigators were seriously speculating that environmental influences might be capable of altering brain structure. By 1964, two research laboratories proved that the morphology and chemistry or physiology of the brain could be experientially altered (Bennett et al. 1964, Hubel and Wiesel 1965). Since then, the capacity of the brain to respond to environmental input, specifically "enrichment,'' has become an accepted fact among neuroscientists, educators and others. In fact, the demonstration that environmental enrichment can modify structural components of the rat brain at any age altered prevailing presumptions about the... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Enrichment; Cerebral cortex; Hippocampus; Aging; Adult neurogenesis; Dendrites. |
Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000200006 |
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Torres,I.L.S.; Gamaro,G.D.; Silveira-Cucco,S.N.; Michalowski,M.B.; Corrêa,J.B.; Perry,M.L.S; Dalmaz,C.. |
It has been suggested that glucocorticoids released during stress might impair neuronal function by decreasing glucose uptake by hippocampal neurons. Previous work has demonstrated that glucose uptake is reduced in hippocampal and cerebral cortex slices 24 h after exposure to acute stress, while no effect was observed after repeated stress. Here, we report the effect of acute and repeated restraint stress on glucose oxidation to CO2 in hippocampal and cerebral cortex slices and on plasma glucose and corticosterone levels. Male adult Wistar rats were exposed to restraint 1 h/day for 50 days in the chronic model. In the acute model there was a single exposure. Immediately or 24 h after stress, the animals were sacrificed and the hippocampus and cerebral... |
Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Restraint stress; Chronic stress; CO2 production; Glucose oxidation; Hippocampus; Cerebral cortex. |
Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000100013 |
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Silva,A.R.; Ruschel,C.; Helegda,C.; Wyse,A.T.S.; Wannmacher,C.M.D.; Wajner,M.; Dutra-Filho,C.S.. |
2-Hydroxybutyric acid appears at high concentrations in situations related to deficient energy metabolism (e.g., birth asphyxia) and also in inherited metabolic diseases affecting the central nervous system during neonatal development, such as "cerebral" lactic acidosis, glutaric aciduria type II, dihydrolipoyl dehydrogenase (E3) deficiency, and propionic acidemia. The present study was carried out to determine the effect of 2-hydroxybutyric acid at various concentrations (1-10 mM) on CO2 production and lipid synthesis from labeled substrates in cerebral cortex of 30-day-old Wistar rats in vitro. CO2 production was significantly inhibited (30-70%) by 2-hydroxybutyric acid in cerebral cortex prisms, in total homogenates and in the mitochondrial fraction. We... |
Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Lipid synthesis; Energy metabolism; Cerebral cortex; 2-hydroxybutyric acid. |
Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500010 |
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Irnidayanti,Yulia; Darmanto,Win. |
One of the plastic base material, widely used in the plastics industry in various countries, is a ester phthalate. These compounds will be oxidizedin the body to 2-methoxyethanol (2-ME). Effect of 2-ME on human health and the environment depends on the number, duration and frequency of exposure. 2-ME and its metabolites in the body can damage cells and tissues. The body can be exposed by 2-ME through the air, water and soil. Western blot results showed that the protein Vimentin was detectable in the control group at GD-11 to 17, meanwhile GFAP protein was detachable in the control group atGD- 12 to GD-18. After administration 2-ME, the expression of Vimentinprotein were changed, and started at GD- 12 up to GD-18. whereas the expression of GFAP protein... |
Tipo: Journal article |
Palavras-chave: 2-methoxyethanol; Vimentin; GFAP; Cerebral cortex; Brain. |
Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300003 |
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Ghanbari,Ali; Kakebaraei,Seyran; Khazaei,Mozafar. |
Neuroleptic drugs such as haloperidol has side effects on extrapyramidal pathways. Tardive Dyskinesia is the most important complication. The most characteristic feature of this Tardive Dyskinesia is involuntary movements of mouth and face. In regard to this problem, the induction of gliosis and cell death in the nervous tissue are considered. In this study, adult Sprague-Dawley rats were used as experimental models. Rats were divided into control and experimental groups. The rats were kept in the animal house under standard conditions during experiments. The control rats were intraperitoneally treated with normal saline for 6 days. The experimental samples were treated for the same time with 2, 5 and 10 mg haloperidol. After the trial period, the rats... |
Tipo: Journal article |
Palavras-chave: Haloperidol; Cerebral cortex; Optical microscopy; Cell death; Rat. |
Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000400046 |
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Ekong,Moses B; Peter,Aniekan I; Ekpene,Ubong U; Bassey,Enobong I; Eluwa,Mokutima A; Akpanabiatu,Monday I; Ekanem,Theresa B. |
Rauwolfia vomitoria (RV) has potent sedative effect, which may result in severe unpleasant consequences if not controlled. This necessitated this study on the effect of Gongronema latifolium (GL) on RV-induced behaviour, biochemical activities, and histomorphology of the cerebral cortex. Eighteen male Wistar rats of average weight 266 g were grouped into three (13). Group 1 was the control administered 0.5 mL of Tween®20, while groups 2 and 3 were administered 150 mg/kg of RV, and a combination of 150 mg/kg of RV and 200 mg/kg of GL (RV+GL), respectively for seven days. Twelve hours after treatments, open field neurobehavioral test was carried-out and the animals euthanized. Their sera were analyzed, and their cerebral cortices routinely processed by... |
Tipo: Journal article |
Palavras-chave: Rauwolfia vomitoria; Gongronema latifolium; Behavior; Enzymes; Lipid; Cerebral cortex; Histomorphology. |
Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100013 |
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Lyras, G.A.. |
Canid brain evolution followed three independent, yet convergent paths. Each of the three canid subfamilies (Hesperocyoninae, Borophaginae and Caninae) started with a simple brain, which gradually became more complicated as the cerebral cortex became larger and more fissured, the cerebellar hemispheres became larger and the vermis more twisted. The extent to which these evolutionary changes took place differs between the three canid subfamilies. Caninae, the living group, has the most advanced external brain anatomy. This is related to the general tendency of the carnivore brain to become more convoluted through geological time. A parallel development of similar sulcal patt erns took place in independent lineages within the Canidae. As a result, some... |
Tipo: Article / Letter to the editor |
Palavras-chave: Palaeoneurology; Cerebral cortex; Cortical folding; Craniodental adaptations; 38.22; 42.84. |
Ano: 2009 |
URL: http://www.repository.naturalis.nl/record/313865 |
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Registros recuperados: 13 | |
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