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| Maillet, A; Congy Jolivet, N; Le Guellec, S; Vecellio, L; Hamard, S; Courty, Y; Courtois, Anthony; Gauthier, F; Diot, P; Thibault, G; Lemarie, E; Heuze Vourc' H, N. |
| Purpose. Despite an increasing interest in the use of inhalation for local delivery of molecules for respiratory diseases and systemic disorders, methods to deliver therapy through air-ways has received little attention for lung cancer treatment. However, inhalation of anticancer drugs is an attractive alternative route to systemic administration which results in limited concentration of the medication in the lungs, and triggers whole-body toxicity. In this study, we investigated the feasibility of nebulization for therapeutic antibodies, a new class of fully-approved anticancer drugs in oncology medicine. Materials and methods. Cetuximab, a chimeric IgG1 targeting the epidermal growth factor receptor (EGER), was nebulized using three types of delivery... |
| Tipo: Text |
Palavras-chave: Nebulizer; Lung cancer; Cetuximab; Anticancer antibody; Aggregation; Aerosol. |
| Ano: 2008 |
URL: http://archimer.ifremer.fr/doc/2008/publication-4201.pdf |
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| Zhang,S.; Zhang,Y.; Qu,J.; Che,X.; Fan,Y.; Hou,K.; Guo,T.; Deng,G.; Song,N.; Li,C.; Wan,X.; Qu,X.; Liu,Y.. |
| Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including tumor invasion, metastasis, and drug resistance. In this study, exosomes derived from cetuximab-resistant RKO colon cancer cells induced cetuximab resistance in cetuximab-sensitive Caco-2 cells. Meanwhile, exosomes from RKO and Caco-2 cells showed different levels of phosphatase and tensin homolog (PTEN) and phosphor-Akt. Furthermore, reduced PTEN and increased phosphorylated Akt levels were found in Caco-2 cells after exposure to RKO cell-derived exosomes.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cetuximab; Exosome; PTEN; Akt; Colon cancer. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100609 |
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| Benedetto,Raquel; Massicano,Adriana Vidal Fernandes; Silva,Jefferson Jesus; Boas,Cristian Antonio Wieczorek Villas; Mengatti,Jair; Araújo,Elaine Bortoleti de. |
| ABSTRACT Scientific innovations in diagnostic methods are important drivers of cancer control and prevention. Noninvasive imaging of the epidermal growth factor receptor (EGFR) in head-and-neck squamous, cell carcinoma and colorectal cancer could be valuable to select patients for EGFR-targeted therapy, as well as to monitor the efficacy and occurrence of resistance to immunotherapy. In order to develop the first Brazilian radioimmunoconjugate for diagnosis, Cetuximab has been conjugated to p-SCN-Bn-DTPA chelator and radiolabeled with Indium-111. The conjugation methodology was optimized using different mAb:DTPA molar ratios, time was then reduced for immunoconjugate preparation, besides the protein recovery’ percentage increased after purification (m =... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Radioimmunoconjugate/development; Head and neck cancer/diagnosis; Tumors diagnosis; Cetuximab; SPECT; 111In. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400624 |
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