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| Teunis, Peter Fm; Le Guyader, Soizick; Liu, Pengbo; Ollivier, Joanna; Moe, Christine L. |
| Noroviruses are a major public health concern: their high infectivity and environmental persistence have been documented in several studies. Genetic sequencing shows that noroviruses are highly variable, and exhibit rapid evolution. A few human challenge studies have been performed with norovirus, leading to estimates of their infectivity. However, such incidental estimates do not provide insight into the biological variation of the virus and the interaction with its human host. To study the variation in infectivity and pathogenicity of norovirus, multiple challenge studies must be analysed jointly, to compare their differences and describe how virus infectivity and host susceptibility vary. Since challenge studies can only provide a small sample of the... |
| Tipo: Text |
Palavras-chave: Challenge studies; Infectivity; Natural experiments; Norovirus; Multilevel dose response. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00641/75265/75474.pdf |
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