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Evaluation of polyelectrolyte and emulsion covalent crosslink of chitosan for producing mesalasine loaded submicron particles BJPS
Lacerda,Gabriel José Silveira; Piantino,Beatriz Lemos; Gonzaga,Edeilson Vitor; Naves,Valéria de Moura Leite; Pedreiro,Liliane Neves; Gremião,Maria Palmira Daflon; Pereira,Gislaine Ribeiro; Carvalho,Flávia Chiva.
This study evaluates various techniques for producing mesalamine (5ASA)-loaded particles employing chitosan as a biopolymer: (1) the polyelectrolyte complexation of chitosan with phthalate hypromelose (HP), (2) the chemical crosslinking of chitosan with genipin and (3) the water-in-oil emulsion method associated with chemical crosslinking with genipin. Systems were characterized by dynamic light scattering, zeta potential (ζ), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR) and a drug release profile. Method (1) was efficiently produced unloaded nanoparticles (491 nm, PdI=0.26 and ζ = 23.2), but the conditions for chitosan and HP cross-linking enhanced the precipitation of 5ASA. Method (2) caused the degradation of the drug....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Emulsion method; Polyelectrolyte crosslinking; Chemical cross-linking; Chitosan; Mesalazine.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100602
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Molecular Organization and Cross-linking Analysis of the Plasmodium falciparum Erythrocyte Binding Proteins Rhop-H and SERA OAK
Sam-Yellowe, Tobili Y.; Fujioka, Hisashi; Aikawa, Masamichi; Messineo, Daniela G.; Leash, Aaron M.; Hall, Ted; Drazba, Judya A.; Ndengele, Micheael M..
Palavras-chave: High molecular weight rhoptry protein complex; Rhoptry protein; Erythrocyte binding proteins (EBPs); Chemical cross-linking.
Ano: 2000 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/341
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