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	Provedor de dados BJMBR (1) International Journal of Morphology (1) Autor Mardones,Rodrigo (1) Martínez,Rafael (1) Paredes,María Jose (1) Qiao,Y.J. (1) Shan,X.B. (1) Wang,H. (1) Zalaquett,Eugenio (1) Mais... Palavra-chave Chondrogenic differentiation (2) C-Jun N-terminal kinase (JNK) (1) Mesenchymal Stem Cells (1) Mesenchymal stem cell (1) Osteoarthritis (1) Pyruvate dehydrogenase kinase isoform 2 (1) SRY-related high mobility group-box 6 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2017 (1) 2010 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última PDK2 promotes chondrogenic differentiation of mesenchymal stem cells by upregulation of Sox6 and activation of JNK/MAPK/ERK pathway BJMBR Wang,H.; Shan,X.B.; Qiao,Y.J.. This study was undertaken to clarify the role and mechanism of pyruvate dehydrogenase kinase isoform 2 (PDK2) in chondrogenic differentiation of mesenchymal stem cells (MSCs). MSCs were isolated from femurs and tibias of Sprague-Dawley rats, weighing 300-400 g (5 females and 5 males). Overexpression and knockdown of PDK2 were transfected into MSCs and then cell viability, adhesion and migration were assessed. Additionally, the roles of aberrant PDK2 in chondrogenesis markers SRY-related high mobility group-box 6 (Sox6), type ΙΙ procollagen gene (COL2A1), cartilage oligomeric matrix protein (COMP), aggrecan (AGC1), type ΙX procollagen gene (COL9A2) and collagen type 1 alpha 1 (COL1A1) were measured by quantitative reverse-transcription polymerase chain... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pyruvate dehydrogenase kinase isoform 2; Chondrogenic differentiation; Mesenchymal stem cell; SRY-related high mobility group-box 6; C-Jun N-terminal kinase (JNK). Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200606 Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells: First Successful Latin-American Report International Journal of Morphology Mardones,Rodrigo; Martínez,Rafael; Paredes,María Jose; Zalaquett,Eugenio. Osteoarthritis is the more frequent cause of disability in adult people and it is associated to cartilage degeneration of affected joints. This cartilage has a limited ability to repair. Several treatments have been tested including the use of Mesenchymal Stem Cells. These cells are an attractive source for cartilage repair because of their availability to chodrogenic differentiation by progressing sequentially through the expression of cartilage specific extracelullar matrix molecules, as in the embryologic human development. The aim is to obtain, culture and differentiate rabbit Bone Marrow derived Mesenchymal Stem Cells in vitro to chondral lineage. By differential centrifugation the mononuclear cell level was obtained from rabbit bone marrow samples.... Tipo: Journal article Palavras-chave: Chondrogenic differentiation; Mesenchymal Stem Cells; Osteoarthritis. Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300014 Registros recuperados: 2 Primeira ... 1 ... Última

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