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| Vargas Guerrero,Belinda; García López,Pedro M; González Santiago,Ana E; Domínguez Rosales,José A; Gurrola Díaz,Carmen M. |
| Objective: The high global incidence of type 2 diabetes has challenged researchers to establish animal models that resemble the chronic stage observed in type 2 diabetes patients. One such model is induced by neonatal streptozotocin (n-STZ) administration to rat pups at 0, 2, or 5 days after birth. In this study, we assessed lns-1 gene expression and tissue insulin levels as well as serum concentration of glucose and insulin, insulin resistance, and histological changes of the islets of Langerhans in n5-STZ rats after 20-weeks post-induction. Methods: Wistar rat pups were randomly distributed into a control group and a streptozotocin-induced group. Experimental induction involved a single intraperitoneal injection of streptozotocin (150 mg/kg) into... |
| Tipo: Journal article |
Palavras-chave: Chronic hyperglycemia; In vivo diabetes models; Lns-1 gene; Type 2 diabetes. |
| Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000300009 |
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