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Comparison of morning and afternoon exercise training for asthmatic children BJMBR
Silva,C.S.; Torres,L.A.G.M.M.; Rahal,A.; Terra Filho,J.; Vianna,E.O..
Fitness improvement was used to compare morning with afternoon exercise periods for asthmatic children. Children with persistent moderate asthma (according to GINA criteria), 8 to 11 years old, were divided into 3 groups: morning training group (N = 23), afternoon training group (N = 23), and non-training group (N = 23). The program was based on twice a week 90-min sessions for 4 months. We measured the 9-min running distance, resting heart rate and abdominal muscle strength (sit-up number) before and after the training. All children took budesonide, 400 µg/day, and an on demand inhaled ß-agonist. The distance covered in 9 min increased (mean ± SEM) from 1344 ± 30 m by 248 ± 30 m for the morning group, from 1327 ± 30 m by 162 ± 20 m for the afternoon...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Children; Chronotherapy; Exercise training; Circadian rhythm; Exercise-induced bronchospasm.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100008
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Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases BJPS
Martins,Sarah Moherdaui; Müller,Vinicius; Galan,Vanderson; Souza,Fabio Pinheiro de; Andreazza,Itamar Francisco; Rosa,Maurício Ferreira da.
Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of circadian diseases. This system was obtained by the combination of cellulosic polymers hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) in a 2² factorial experimental design, which allowed the optimization of the development stage. The pellets produced and used in biphasic formulations were evaluated for physical and chemical characteristics and presented acceptable results. The immediate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronotherapy; Biphasic Release; Pellets; Cellulosic Polymers; Experimental Design.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400607
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