|
|
|
|
|
| Arribada,Raquel Gregorio; Pereira,Nara Caroline; Cardoso,Valbert Nascimento; Cunha Júnior,Armando da Silva; Barros,André Luís Branco de. |
| Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and significant kidney uptake, indicating that 99mTc-CDV is preferentially eliminated by the renal route. Bones also showed important uptake throughout the experiment. In summary, cidofovir was successfully labeled with technetium-99m and might be used in further studies to track the drug. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cidofovir; Radiotracer; Technetium-99m; Biodistribution; Scintigraphic imaging. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100570 |
| |
|
|
| Oliveira,Amanda Lovato de; Cargnelutti,Juliana Felipetto; Mortari,Ana Paula Gnocato; Flores,Eduardo Furtado; Weiblen,Rudi. |
| ABSTRACT: Equid alphaherpesvirus type 1 (EHV-1) is distributed worldwide and is a major agent of abortion, respiratory and neurological disease in horses. No specific treatment is available for EHV-1 infection, yet the potential of antiviral therapy has been explored. In this study we investigated the in vitro activity of Acyclovir, Ganciclovir, Foscarnet, Famciclovir, Vidarabina and Cidofovir against EHV-1. For this, the MTT test was performed, in which all the tested drugs showed no toxicity up to 200μg/mL. Subsequently, different drug concentrations were submitted to viral plaque reduction assays in cell culture. The selectivity index (SI) of the compounds was determined using the cytotoxic concentration for 50% of cells (CC50), obtained by MTT, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: EHV-1; Plaque assay; Acyclovir; Ganciclovir; Foscarnet; Famciclovir; Vidarabine; Cidofovir. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018001200450 |
| |
|
|
|
