|
|
|
|
|
| Hernández González, Carlos Manuel. |
| En la actualidad para que un medicamento sea autorizado para consumo humano se deben realizar extensas pruebas de seguridad y eficacia. La investigación clínica se ocupa de llevar a cabo dichas pruebas o ensayos clínicos. En este trabajo se desarrollaron una serie de programas que producen tablas estadísticas para la presentación de resultados de una investigación clínica. Los programas se desarrollaron usando el paquete estadistico SAS® (Statistical Analysis System), debido a que es uno de los sistemas de cómputo más importantes para el procesamiento y analisis estadístico de datos. Estos programas nos permiten producir algunas de las tablas mas frecuentemente requeridas en los reportes de los resultados de una investigación clinica de acuerdo a la... |
| Tipo: Tesis |
Palavras-chave: Investigación clínica; Seguridad y eficacia; Maestría; Estadística; Clinical investigation; Security and efficacy. |
| Ano: 2008 |
URL: http://hdl.handle.net/10521/1616 |
| |
|
|
| Fragoso Sandoval, María. |
| Se desarrollaron programas en código SAS®, para producir cuadros estadísticos típicos para la presentación de resultados en el reporte de una investigación clínica. Se presenta la forma de utilizar los programas y se dan ejemplos. La utilización de estos programas facilita y mejora la presentación de la información y disminuye el tiempo de programación. ______Programs were developed in code SAS®, to produce typical statistical squares for the presentation of results in the report of a clinical investigation. The form is presented of using the programs and examples are given. The use of these programs facilitates and it improves the presentation of the information and it diminishes the programming time. |
| Tipo: Tesis |
Palavras-chave: SAS®; Investigación clínica; Maestría; Estaadística; Clinical investigation. |
| Ano: 2008 |
URL: http://hdl.handle.net/10521/1535 |
| |
|
|
| Giugliani,Luciana; Vanzella,Claudia; Zambrano,Marina Bauer; Donis,Karina Carvalho; Wallau,Thaís Klassmann Wendland; Costa,Fernando Machado da; Giugliani,Roberto. |
| Abstract Rare diseases are defined as conditions with a prevalence of no more than 6.5 per 10,000 people. Although each rare disease individually affects a small number of people, collectively, the 6,000 to 8,000 rare conditions (80% of them with genetic cause) affect around 8% of the world’s population. Research about the natural history and underlying pathophysiological mechanisms of rare diseases, as well as clinical trials with new drugs, are important and necessary to develop new strategies for the treatment of these conditions. This report describes the experience of a clinical research group working with rare diseases in a reference center for lysosomal diseases in Brazil (Medical Genetics Service, Hospital de Clínicas de Porto Alegre). The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Clinical research; Clinical investigation; Rare diseases; Lysosomal storage diseases; Enzyme replacement therapy. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200305 |
| |
|
|
| Silva,Gisleine Elisa Cavalcante da; Assef,Abdol Hakin; Albino,Claudio Cordeiro; Ferri,Letícia de Araujo Funari; Tasin,Gilson; Takahashi,Mirian Hideko; Eik Filho,Wilson; Bazotte,Roberto Barbosa. |
| The tolerability of stevioside (2.75 mg/kg/day) obtained from leaves of Stevia rebaudiana (Bert) Bertoni (Compositae) was investigated in hyperlipidemic patients. For this purpose a placebo controlled double blind study was performed. The patients were randomized in two groups: the first group received capsules containing placebo and the second group received capsules containing stevioside (50 mg) during 90 days. All capsules were ingested twice daily, i.e., 2 capsules before lunch and 2 capsules before dinner. After the selection of the patients and each 30 days body mass index and laboratory tests (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, total cholesterol, high density lipoprotein, low density lipoprotein, very... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Stevia rebaudiana (Bert) Bertoni; Stevioside; Clinical investigation; Placebo effect. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500007 |
| |
|
| |
|
|
|
