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	Provedor de dados BJPS (2) Autor Chickpetty,Sidramappa Mallikarjun (1) Kandhasami,Uma Devi Subbaih (1) Raga,Baswaraj Veerappa (1) Ramasamy,Thiruganesh (1) Ruttala,Himabindhu (1) Shanmugam,Suresh (1) Mais... Palavra-chave Colon targeting (2) 5-fluorouracil (1) Aceclofenac/release colon targeted (1) Colon cancer and X-ray (1) Compression coated tablet (1) Drugs/release colon targeted (1) Eudragit coating (1) In vitro dissolution (1) Locust bean gum (1) Targeted delivery (1) Xanthan gum (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Formulation and evaluation of xanthan gum based aceclofenac tablets for colon targeted drug delivery BJPS Ramasamy,Thiruganesh; Kandhasami,Uma Devi Subbaih; Ruttala,Himabindhu; Shanmugam,Suresh. The objective of the present study is to develop a colon targeted drug delivery systems for Aceclofenac using xanthan gum as a carrier. In this study, multilayer coated system that is resistant to gastric and small intestinal conditions but can be easily degraded by colonic bacterial enzymes was designed to achieve effective colon delivery of Aceclofenac. The xanthan gum, the drug and the physical mixture were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). All the formulations were evaluated for hardness, drug content uniformity and other physical properties. Release aspects of Aceclofenac in simulated gastrointestinal fluid and colonic fluid with enzymes were investigated. From these results,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/release colon targeted; Aceclofenac/release colon targeted; Xanthan gum; Colon targeting; Eudragit coating; In vitro dissolution; Targeted delivery. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200011 Formulation, in vitro drug release and in vivo human X-ray investigation of polysaccharide based drug delivery systems for targeting 5-fluorouracil to the colon BJPS Chickpetty,Sidramappa Mallikarjun; Raga,Baswaraj Veerappa. The purpose of this research study was to develop 5-fluorouracil compression coated tablets by using biodegradable polysaccharide polymer locust bean gum (LBG) and hydroxyl propyl methyl cellulose (HPMC) as coating materials. The fast disintegrating core tablets containing 50 mg of 5-fluorouracil were compression coated with LBG and HPMC in different ratios (8:1, 7:2 and 6:3) with a coat weight of 300, 400 and 500 mg. In vitro dissolution data indicated that the formulation (CLH63) with a coat weight of 500 mg containing LBG and HPMC in the ratio 6:3 gave the best release profile (0% in first 5 hour and 96.18% in 24 hours). DSC and FTIR results indicated no possibility of interaction between drug and polymers or other excipients. In vivo human X-ray... Tipo: Info:eu-repo/semantics/article Palavras-chave: Compression coated tablet; Locust bean gum; Colon targeting; 5-fluorouracil; Colon cancer and X-ray. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200008 Registros recuperados: 2 Primeira ... 1 ... Última

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