|
|
|
|
|
| Peixoto Júnior,A.A.; Teles,B.C.V; Castro,E.F.B.; Santos,A.A.; de Oliveira,G.R.; Ribeiro,R.A.; Rola,F.H.; Gondim,F.A.A.. |
| We evaluated the effects of vincristine on the gastrointestinal (GI) motility of awake rats and correlated them with the course of vincristine-induced peripheral neuropathy. Vincristine or saline was injected into the tail vein of male Wistar rats (180-250 g) on alternate days: 50 µg/kg (5 doses, N = 10), 100 µg/kg (2, 3, 4 and 5 doses, N = 49) or 150 µg/kg (1, 2, or 5 doses, N = 37). Weight and stool output were measured daily for each animal. One day after completing the vincristine treatment, the animals were fasted for 24 h, gavage-fed with a test meal and sacrificed 10 min later to measure gastric emptying (GE), GI transit and colon weight. Sensory peripheral neuropathy was evaluated by hot plate testing. Chronic vincristine treatments with total... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Constipation; Gastrointestinal transit; Peripheral neuropathy; Rat gastric emptying; Vincristine. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600015 |
| |
|
|
| Bellomo-Brandão,M.A.; Collares,E.F.; da-Costa-Pinto,E.A.L.. |
| The efficacy of erythromycin was assessed in the treatment of 14 children aged 4 to 13 years with refractory chronic constipation, and presenting megarectum and fecal impaction. A double-blind, placebo- controlled, crossover study was conducted at the Pediatric Gastroenterology Outpatient Clinic of the University Hospital. The patients were randomized to receive placebo for 4 weeks followed by erythromycin estolate, 20 mg kg-1 day-1, divided into four oral doses for another 4 weeks, or vice versa. Patient outcome was assessed according to a clinical score from 12 (most severe clinical condition) to 0 (complete recovery). At enrollment in the study and on the occasion of follow-up medical visits at two-week intervals, patient score and laxative requirements... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Gastrointestinal motility; Constipation; Children; Prokinetics; Erythromycin. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000016 |
| |
|
| |
|
| |
|
|
| Guimarães,E.V.; Goulart,E.M.A.; Penna,F.J.. |
| The objective of the present study was to evaluate associations between fiber intake, colonic transit time and stool frequency. Thirty-eight patients aged 4 to 14 years were submitted to alimentary evaluation and to measurement of colonic transit time. The median fiber intake of the total sample was age + 10.3 g/day. Only 18.4% of the subjects presented a daily dietary fiber intake below the levels recommended by the American Health Foundation. In this group, the median left colonic transit time was shorter than in the group with higher dietary fiber intake (11 vs 17 h, P = 0.067). The correlation between stool frequency and colonic transit time was negative and weak for left colon (r = -0.3, P = 0.04), and negative and moderate for rectosigmoid and total... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Children; Constipation; Dietary fiber; Colonic transit time. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000900007 |
| |
|
|
|
