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| Laskoski,L. M.; Dittrich,R. Locatelli; Valadão,C. A. A; Castro,M. L.; Araujo,F. F.; Silva,J. R.; Basso,F. Z.; Dornbusch,P. T.; Deconto,I.; Sousa,R. S.. |
| ABSTRACTLaminitis in horses is often associated with endocrine disorders, especially the pituitary pars intermedia dysfunction (PPID) in older animals. Morphologic exams of the laminar tissue of the hoof were performed in two horses with suspected PPID, with no clinical signs of laminitis. Changes compatible with laminitis of endocrine origin were observed, such as rounding of the nuclei of the basal cells, thinning and stretching of the secondary epidermal laminae and tissue proliferation. PPID horses with no clinical signs of laminitis may be affected by lesions of the laminar tissue of the hoof that compromise the integrity of the dermal-epidermal junction and may develop clinical symptoms of the disease. It has been suggested that the development stage... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Laminitis; Metabolic syndrome; Cushing's syndrome; Endocrine disorders; Pituitary adenoma. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000501226 |
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| Kasperlik-Zaluska,A.A.. |
| Mitotane (o,p'-DDD) acts mainly as an inhibitor of intramitochondrial pregnenolone and cortisol synthesis. Its adrenolytic effect depends on metabolic activation due to conversion to o,p'-DDA and o,p'-DDE. The drug has been used for 40 years in the treatment of adrenocortical carcinoma, mainly its regional and metastatic stage, as an adjuvant to surgical resection of the tumor. In the medical literature there are controversial opinions about its efficacy for the treatment of adrenocortical carcinoma. In our experience, mitotane administered immediately after surgery appeared to be much more efficient than when administered later. We have administered this drug in all cases of microscopically confirmed adrenocortical carcinoma, irrespectively of stage at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mitotane; Adrenocortical carcinoma; Cushing's syndrome. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000008 |
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| Lanna,C.M.M.; Paula,F.J.A.; Montenegro Jr.,R.M.; Moreira,A.C.; Foss,M.C.. |
| Osteoporosis is a common manifestation of Cushing's syndrome, but the mechanisms responsible for this abnormality have not been defined. With the objective of analyzing parathyroid hormone (PTH) secretion in chronic hypercortisolism (CH), we evaluated 11 healthy subjects and 8 patients with CH, 6 with Cushing's disease and 2 with adrenal adenoma. These volunteers were submitted to tests of PTH stimulation through hypocalcemia (EDTA), PTH suppression through hypercalcemia (iv and oral calcium), and evaluation of bone mineral density (BMD) by DEXA. During the test of PTH stimulation, the calcium and magnesium concentrations of the normal and CH groups were similar. Patients with CH showed an increased PTH response to the hypocalcemic stimulus compared to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parathyroid hormone; Calcium; EDTA; Hypercortisolism; Cushing's syndrome; Osteoporosis. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200012 |
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