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	Provedor de dados BJID (1) BJPS (1) Autor Bergamaschi,Mateus Machado (1) Bianchi,Maria de Lourdes Pires (1) Bragheto,Juliana Bordinassi (1) Malfará,Wilson Roberto (1) Martins,Ana de Nazaré Silva (1) Moraes,Natália Valadares de (1) Queiroz,Regina Helena Costa (1) Riveira,Juan Gonzalo Bardarez (1) Salgado,Claudio Guedes (1) Silva,Jorge Pereira da (1) Vieira,Jose Luiz Fernandes (1) Mais... Palavra-chave Dapsone (2) L-NAME (1) L-arginine (1) Leprosy (1) Methahemoglobinemia (1) Methemoglobinemia (1) Nitric oxide (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2012 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Methemoglobinemia and dapsone levels in patients with leprosy BJID Vieira,Jose Luiz Fernandes; Riveira,Juan Gonzalo Bardarez; Martins,Ana de Nazaré Silva; Silva,Jorge Pereira da; Salgado,Claudio Guedes. The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia. Tipo: Info:eu-repo/semantics/other Palavras-chave: Methahemoglobinemia; Dapsone; Leprosy. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300022 L-arginine, a nitric oxide precursor, reduces dapsone-induced methemoglobinemia in rats BJPS Moraes,Natália Valadares de; Bergamaschi,Mateus Machado; Bianchi,Maria de Lourdes Pires; Bragheto,Juliana Bordinassi; Malfará,Wilson Roberto; Queiroz,Regina Helena Costa. Dapsone use is frequently associated to hematological side effects such as methemoglobinemia and hemolytic anemia, which are related to N-hydroxylation mediated by the P450 enzyme system. The aim of the present study was to evaluate the influence of L-arginine supplementation, a precursor for the synthesis of nitric oxide, as single or multiple dose regimens on dapsone-induced methemoglobinemia. Male Wistar rats were treated with L-arginine at 5, 15, 30, 60 and 180 mg/kg doses (p.o., gavage) in single or multiple dose regimens 2 hours prior to dapsone administration (40 mg/kg, i.p.). The effect of the nitric oxide synthase inhibitor L-NAME was investigated by treatment with multiple doses of 30 mg/kg (p.o., gavage) 2 hours before dapsone administration.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dapsone; Methemoglobinemia; L-arginine; Nitric oxide; L-NAME. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100010 Registros recuperados: 2 Primeira ... 1 ... Última

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