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Glycogen levels and energy status of the liver of fasting rats with diabetes types 1 and 2 BABT
Oliveira,Denise Silva de; Amado,Ciomar Aparecida Bersani; Martini,Mirian Carvalho; Suzuki-Kemmelmeier,Fumie; Bracht,Adelar.
Glycogen levels and the energy status of livers from fasting rats with diabetes types 1 and 2 were measured. After a 24 h fast, the hepatic glycogen levels of rats with diabetes1 and diabetes2 were, 18.7 and 2.6 times higher, respectively, than those of livers from the normal rats. In diabetes1 rats, the glycogen levels decreased when the fasting period was extended to 48 and 72 h. The opposite occurred with the control and diabetes2 rats. Consistently, glucose release by the perfused livers from diabetes1 rats was considerably higher during at least 60 minutes after initiating perfusion. The hepatic ATP content of diabetes1 rats was similar to that of the control rats; in diabetes2 rats, the hepatic ATP content was increased. It could be concluded that...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes type 1; Diabetes type 2; Rats; Hepatic glycogen; Hepatic energy status.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000500006
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Residual ß-cell function and microvascular complications in type 1 diabetic patients BJMBR
Gomes,M.B.; Gonçalves,M.F.R.; Neves,R.; Cohen,C.; Albanesi,F.M..
To determine the influence of residual ß-cell function on retinopathy and microalbuminuria we measured basal C-peptide in 50 type 1 diabetic outpatients aged 24.96 ± 7.14 years, with a duration of diabetes of 9.1 ± 6.2 years. Forty-three patients (86%) with low C-peptide (&lt;0.74 ng/ml) had longer duration of diabetes than 7 patients (14%) with high C-peptide (<FONT FACE="Symbol">³</font>0.74 ng/ml) (9 (2-34) vs 3 (1-10) years, P = 0.01) and a tendency to high glycated hemoglobin (HBA1) (8.8 (6-17.9) vs 7.7 (6.9-8.7)%, P = 0.08). Nine patients (18%) had microalbuminuria (two out of three overnight urine samples with an albumin excretion rate (AER) <FONT FACE="Symbol">³</font>20 and &lt;200 µg/min) and 13 (26%) had...
Tipo: Info:eu-repo/semantics/article Palavras-chave: C-peptide; Microalbuminuria; Retinopathy; Diabetes type 1.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200008
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