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| Araújo,Adriano Antunes Souza; Bezerra,Marília dos Santos; Storpirtis,Sílvia; Matos,Jivaldo do Rosário. |
| The determination of chemical purity, melting range, and variation of enthalpy in the process of characterizing medicines is one of the principal requirements evaluated in quality control of the pharmaceutical industry. In this study, the method of purity determination using DSC was outlined, as well as the application of this technique for the evaluation of commercial samples of zidovudine (AZT) (raw material) supplied by different laboratories. To this end, samples from six different laboratories (A, B, C, D, E, and F) and the standard reference (R) from the United States Pharmacopeia (USP) were analyzed. The DSC curves were obtained in the temperature range of 25 to 200 ºC under the dynamic atmosphere of N2 (50 mL min-1), heating rate of β=2 ºC min-1,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Zidovudine/purity determination; Differential scanning calorimetry; Thermal analysis; Medicines/quality control; Medicines/qualitative analysis. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100005 |
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| OLIVEIRA,Aryane Ribeiro; RIBEIRO,Alline Emannuele Chaves; OLIVEIRA,Érica Resende; GARCIA,Marina Costa; SOARES JÚNIOR,Manoel Soares; CALIARI,Márcio. |
| Abstract The objective of this study was to characterize the structural and physicochemical properties, the bioactive compounds and the antioxidant activity of freeze-dried açaí pulp (FDAP). The morphology of freeze-dried açaí pulp showed a continuous matrix with a spongey aspect, and the X-ray diffractometry indicated that 96.17% of the molecular structure was in the amorphous state and 3.82% in the crystalline state. Freeze-dried açaí pulp presented an interesting chemical composition of macronutrients, which constituted mainly of lipids (49.14 g/100 g d.b.), proteins (9.19 g/100 g d.b.), total crude fiber (20.29 g/100 g d.b.) and total sugars (2.71 g/100 g d.b.). It also showed great amount of total phenolic compounds (1405.03 mg gallic acid/100 g d.b.)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Scanning electron microscopy; Infrared; Differential scanning calorimetry; X-ray diffractometry; Phenolic compounds. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000200282 |
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