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| Ferreira,Guilherme Neves; Silva,Marcos Giovani Rodrigues; Fraga,Aline Guerra Manssour; Silva,Luiz Cláudio Rodrigues Pereira da; Lira,Luiz Marcelo; Rodrigues,Carlos Rangel; Castro,Helena Carla; Sousa,Valéria Pereira de; Cabral,Lucio Mendes. |
| Reproducibility of the tablet manufacturing process and control of its pharmaceutics properties depends on the optimization of formulation aspects and process parameters. Computer simulation such as Design of Experiments (DOE) can be used to scale up the production of this formulation, in particular for obtaining sustained-release tablets. Bromopride formulations are marketed in the form of extended-release pellets, which makes the product more expensive and difficult to manufacture. The aim of this study was to formulate new bromopride sustained release formulations as tablets, and to develop mathematical models to standardize the scale up of this formulation, controlling weight and hardness of the tablets during manufacture according to the USP 34th... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bromopride/extended-release tablets/preparation; Design of experiments; Extended-release tablets/scale up obtention; Direct compression; Tablets/kinetics release. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200291 |
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| Israr,Fozia; Mahmood,Zafar Alam; Hassan,Fouzia; Hasan,Syed Muhammad Farid; Jabeen,Sabahat; Naz,Shazia; Bashir,Lubna. |
| Cefuroxime axetil immediate release tablets were formulated by direct compression method with different percentages of sodium lauryl sulphate (SLS) such as 0.5, 1.0, 1.5 and also without SLS. Resulting batches of tablets were evaluated by both pharmacopeial and non-pharmacopeial methods to ascertain the physico-mechanical properties. Dissolution test were carried out in different medium like 0.07 M HCl, distilled water, 0.1M HCl of pH 1.2 and phosphate buffers at pH 4.5 and 6.8 to observe the drug release against the respective concentration of SLS used. Later, test formulations were compared by f1(dissimilarity) and f2(similarity) factors using a reference brand of cefuroxime axetil. Significant differences (p<0.05) in dissolution rate were recorded... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cefuroxime axetil/immediate release tablets/physico-mechanical properties; Direct compression; Sodium lauryl sulphate. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400943 |
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