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Tracking the Genetic Effects of Global Warming: Drosophila and Other Model Systems Ecology and Society
Scheiner, Samuel M; National Science Foundation; sscheine@nsf.gov.
Current efforts to study the biological effects of global change have focused on ecological responses, particularly shifts in species ranges. Mostly ignored are microevolutionary changes. Genetic changes may be at least as important as ecological ones in determining species' responses. In addition, such changes may be a sensitive indicator of global changes that will provide different information than that provided by range shifts. We discuss potential candidate systems to use in such monitoring programs. Studies of Drosophila subobscura suggest that its chromosomal inversion polymorphisms are responding to global warming. Drosophila inversion polymorphisms can be useful indicators of the effects of climate change on populations and ecosystems. Other...
Tipo: Peer-Reviewed Reports Palavras-chave: Biodiversity conservation; Biological indicator; Chromosomal inversion polymorphism; Climate change; Drosophila; Evolutionary ecology; Genetic diversity; Global warming; Microevolution..
Ano: 1998
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A note on the population genetic consequences of delayed larval development in insects Genet. Mol. Biol.
Salles,Marcos Mattoso de; Otto,Paulo A..
Observations by Dobzhansky's group in the 1940s suggesting that the presence of recessive genotypes could account for lower larval developmental rates in Drosophila melanogaster were not confirmed at the time and all subsequent investigations on this subject focused on the analysis of ecological models based on competition among pre-adult individuals. However, a paper published in this journal in 1991 eventually confirmed the finding made by Dobzhansky and his co-workers. In this report, we provide a theoretical analysis of the population genetic effects of a delay in the rate of larval development produced by such a genetic mechanism.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Difference and differential equations; Drosophila; Dynamic systems; Larval development; Population genetics.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300019
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Distribution and conservation of the transposable element gypsy in drosophilid species Genet. Mol. Biol.
Herédia,Fabiana; Loreto,Elgion Lúcio S.; Valente,Vera Lúcia S..
In an attempt to understand the dynamics of transposable elements (T'S) in the genome of host species, we investigated the distribution, representativeness and conservation of DNA sequences homologous to the Drosophila melanogaster gypsy retrotransposon in 42 drosophilid species. Our results extended the knowledge about the wide distribution of gypsy in the genus Drosophila, including several Neotropical species not previously studied. The gypsy-like sequences showed high divergence compared to the D. melanogaster gypsy element. Furthermore, the conservation of the restriction sites between gypsy sequences from phylogenetically unrelated species pointed to a more complex evolutionary picture, which includes the possibility of the horizontal transfer events...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Retrotransposon; Gypsy; Southern blot; PCR.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100023
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Genetic components affecting embryonic developmental time of Drosophila melanogaster Genet. Mol. Biol.
Nascimento,Jurema Cruz do; Cruz,Ivana Beatrice Mânica da; Monjeló,Luiz Alberto; Oliveira,Alice Kalisz de.
The developmental time of the embryonic stage of Drosophila melanogaster was 21.66% faster and 14.75% slower than controls in populations selected for fast and slow developmental speed, respectively. The genetic model with two main loci with dominant and additive effect added to maternal effect and their relevant interactions can explain 96% of the phenotypic variability in the embryonic developmental time according to 14 crossing progenies involving fast and slow flies.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Developmental rate; Embryo; Drosophila.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000200008
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Drosophila relics hobo and hobo-MITEs transposons as raw material for new regulatory networks Genet. Mol. Biol.
Loreto,Elgion L.S.; Deprá,Maríndia; Diesel,José F.; Panzera,Yanina; Valente-Gaiesky,Vera Lucia S..
Abstract Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and even-skipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hobo; Transposable elements; Cis-regulatory sequences; Drosophila.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200198
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Transposable elements from the mesophragmatica group of Drosophila Genet. Mol. Biol.
Germanos,Erika; Mota,Nina R.; Loreto,Elgion L.S..
Transposable elements (TEs) are middle repetitive DNA sequences classified into families according to their sequence similarities, such elements can playing an important role in the evolutionary process of their host genomes. There are many reports on the distribution of TEs in the fruit fly genus Drosophila, although there is relatively little information relating to the Neotropical mesophragmatica group of Drosophila, probably the most typical cluster of species occurring almost exclusively in the Andes mountains. Dot Blot and PCR analyses was used to study the distribution of some TEs (I, mariner, hobo, gypsy, Tom/17.6, micropia and P elements) within the mesophragmatica group of Drosophila. We found gypsy elements in all the mesophragmatica group...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Mesophragmatica; Phylogenetic distribution; Transposable elements.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000400026
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Evolution of DNMT2 in drosophilids: Evidence for positive and purifying selection and insights into new protein (pathways) interactions Genet. Mol. Biol.
Vieira,Gilberto Cavalheiro; D’Ávila,Marícia Fantinel; Zanini,Rebeca; Deprá,Maríndia; da Silva Valente,Vera Lúcia.
Abstract The DNA methyltransferase 2 (DNMT2) protein is the most conserved member of the DNA methyltransferase family. Nevertheless, its substrate specificity is still controversial and elusive. The genomic role and determinants of DNA methylation are poorly understood in invertebrates, and several mechanisms and associations are suggested. In Drosophila, the only known DNMT gene is Dnmt2. Here we present our findings from a wide search for Dnmt2 homologs in 68 species of Drosophilidae. We investigated its molecular evolution, and in our phylogenetic analyses the main clades of Drosophilidae species were recovered. We tested whether the Dnmt2 has evolved neutrally or under positive selection along the subgenera Drosophila and Sophophora and investigated...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Dnmt2; Positive selection; Epigenetic; Positive-destabilizing selection.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200215
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Geographic polymorphism of P element in populations of Drosophila sturtevanti Genet. Mol. Biol.
Almeida,Luciane M. de; Langeani,Francisco; Carareto,Claudia M.A..
The aim of this report was to detect full-sized P element sequences in eight strains of Drosophila sturtevanti populations from distant geographic regions and to assess the structural geographic variation among P element sequences. PCR analysis confirmed the presence of a putative complete P element in all strains. Southern blot analysis indicated bands shared by all strains, and bands restricted to geographically related strains. Parsimony analysis corroborated the hybridization pattern that reflected the geographic relationships.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Canonical P elements; Drosophila; P element polymorphism; Saltans group; Transposable elements.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000200010
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Enhanced tethered-flight duration and locomotor activity by overexpression of the human gene SOD1 in Drosophila motorneurons Genet. Mol. Biol.
Petrosyan,Agavni; Hsieh,I-Hui; Phillips,John P.; Saberi,Kourosh.
Mutation of the human gene superoxide dismutase (hSOD1) is associated with the fatal neurodegenerative disease familial amyotrophic lateral sclerosis (Lou Gehrig’s disease). Selective overexpression of hSOD1 in Drosophila motorneurons increases lifespan to 140% of normal. The current study was designed to determine resistance to lifespan decline and failure of sensorimotor functions by overexpressing hSOD1 in Drosophila‘s motorneurons. First, we measured the ability to maintain continuous flight and wingbeat frequency (WBF) as a function of age (5 to 50 days). Flies overexpressing hSOD1 under the D42-GAL4 activator were able to sustain flight significantly longer than controls, with the largest effect observed in the middle stages of life. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Behavioral genetics; Superoxide dismutase; Drosophila; Motorneuron; Longevity.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100107
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Distribution and insertion numbers of transposable elements in species of the Drosophila saltans group Genet. Mol. Biol.
Castro,Juliana P. de; Setta,Nathalia de; Carareto,Claudia Marcia A..
Information about the distribution and insertion numbers of many transposable elements is restricted to few species of Drosophila, although these elements are widely distributed throughout the genus. The aim of this work was to describe the distribution and insertion numbers of four retrotransposons (copia, gypsy, micropia, I) and four transposons (hobo, mariner, Minos and Bari-1) in the saltans group of Drosophila. Our data shows that, except for mariner, all the other elements are widespread within the saltans group and show variable insertion numbers of up to 24 copies.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Genomic insertion; Saltans group; Retrotransposons; Transposons.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000200029
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small ORFs: A new class of essential genes for development Genet. Mol. Biol.
Albuquerque,João Paulo; Tobias-Santos,Vitória; Rodrigues,Aline Cáceres; Mury,Flávia Borges; Fonseca,Rodrigo Nunes da.
Genes that contain small open reading frames (smORFs) constitute a new group of eukaryotic genes and are expected to represent 5% of the Drosophila melanogaster transcribed genes. In this review we provide a historical perspective of their recent discovery, describe their general mechanism and discuss the importance of smORFs for future genomic and transcriptomic studies. Finally, we discuss the biological role of the most studied smORF so far, the Mlpt/Pri/Tal gene in arthropods. The pleiotropic action of Mlpt/Pri/Tal in D. melanogaster suggests a complex evolutionary scenario that can be used to understand the origins, evolution and integration of smORFs into complex gene regulatory networks.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tribolium; Mlpt; Pri; Tarsal-less; Drosophila.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000300278
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Chromosomal phylogeny of the Drosophila fasciola species subgroup revisited (Diptera, Drosophilidae) Genet. Mol. Biol.
Diniz,Nilda Maria; Sene,Fabio Melo.
The analysis of polytene chromosomes in 26 strains of seven species in the Drosophila fasciola subgroup, from several locations in Brazil, in addition to strains of two species belonging to the Drosophila mulleri subgroup (D. aldrichi and D. mulleri), enabled us to determine that the 3c inversion found in the latter species differ in one of its break points from that present in the species of the fasciola subgroup. Therefore, a change in the mulleri complex denomination from inversion 3c to inversion 3u is proposed. Accordingly, the fasciola subgroup is no longer a lesser phylogenetic part within the mulleri subgroup. Rather, it is directly related to the likely ancestor of the repleta group, called Primitive I. This information removes the main obstacle...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Chromosome phylogeny; Repleta group; Fasciola subgroup; Chromosome inversions.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400016
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Dmp53, basket and drICE gene knockdown and polyphenol gallic acid increase life span and locomotor activity in a Drosophila Parkinson's disease model Genet. Mol. Biol.
Ortega-Arellano,Hector Flavio; Jimenez-Del-Rio,Marlene; Velez-Pardo,Carlos.
Understanding the mechanism(s) by which dopaminergic (DAergic) neurons are eroded in Parkinson's disease (PD) is critical for effective therapeutic strategies. By using the binary tyrosine hydroxylase (TH)-Gal4/UAS-X RNAi Drosophila melanogaster system, we report that Dmp53, basket and drICE gene knockdown in dopaminergic neurons prolong life span (p < 0.05; log-rank test) and locomotor activity (p < 0.05; χ² test) in D. melanogaster lines chronically exposed to (1 mM) paraquat (PQ, oxidative stress (OS) generator) compared to untreated transgenic fly lines. Likewise, knockdown flies displayed higher climbing performance than control flies. Amazingly, gallic acid (GA) significantly protected DAergic neurons, ameliorated life span, and climbing...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Basket; Dmp53; Drice; Drosophila; Paraquat.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000400020
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Drosophilidae (Diptera) associated to fungi: differential use of resources in anthropic and Atlantic Rain Forest areas Iheringia, Sér. Zool.
Gottschalk,Marco S; Bizzo,Luís; Döge,Jonas S; Profes,Marcos S; Hofmann,Paulo R. P; Valente,Vera L. S.
This study investigates the Drosophilidae species associated to fruiting bodies of fungi in forested and anthropized environments of the Atlantic Rain Forest Biome, in south and southeastern Brazil. We collected samples of imagoes flying over and emerging from fruiting bodies of species of five fungi families, in six collection sites. We obtained 18 samples, from which emerged 910 drosophilids of 31 species from the genera Drosophila Fallen, 1823, Hirtodrosophila Duda, 1923, Leucophenga Mik, 1886, Mycodrosophila Oldenberg, 1914, Scaptomyza Hardy, 1849, Zaprionus Coquillett, 1901 and Zygothrica Wiedemann, 1830. The Drosophila species collected on fungi, as well as Zaprionus indianus Gupta, 1970, had previously been recorded colonizing fruits, demonstrating...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Mycophagous insects; Feeding sites; Breeding sites.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0073-47212009000400016
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Seasonal variation in natural populations of Drosophila spp. (Diptera) in two woodlands in the State of São Paulo, Brazil Iheringia, Sér. Zool.
Torres,Felipe Rafael; Madi-Ravazzi,Lilian.
The composition and the seasonality of the natural populations of Drosophila species in relation to the climatic variables temperature and rainfall were analyzed from September 1998 through October 1999 by monthly collections, in two woodlands in the Northwest of the State of São Paulo, Brazil. The diversity dominance component curves were inclined, reflecting low diversity and high dominance of few species. Among the 25 species recorded, Drosophila sturtevanti Duda, 1927 was the most frequent and abundant. On the opposite to data in literature, D. paranaensis Barros, 1950 abundance and frequency were greater than those from D. mercatorum Patterson &amp; Wheeler, 1942. A positive correlation between abundance and rainfall was observed for D. nebulosa...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brazil; Abiotic factors; Seasonality; Drosophila; Biodiversity.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0073-47212006000400008
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Assemblages of drosophilids (Diptera, Drosophilidae) in mangrove forests: community ecology and species diversity Iheringia, Sér. Zool.
Schmitz,Hermes J.; Hofmann,Paulo R. P.; Valente,Vera L. S..
Brazilian fauna of drosophilids has been researched in various ecosystems, but those in mangrove forests remain overlooked in Brazil and elsewhere. The present study attempts to characterise the assemblages of drosophilids of this environment, based on 28 collections taken in three mangrove areas in Santa Catarina Island, southern Brazil. The three mangroves surveyed were different in their surroundings, which varied from highly urbanised areas to conservation areas with natural vegetation. Overall, 69 species were collected, and no remarkable difference was detected in species composition and abundances or in the richness, evenness and heterogeneity between sites. The species abundance distribution observed fitted to a theoretical lognormal distribution...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Biodiversity; Diversity measures; Drosophila; Neotropical region; Source-sink hypothesis.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0073-47212010000200008
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Two new species of the Drosophila serido sibling set (Diptera, Drosophilidae) Iheringia, Sér. Zool.
Tidon-Sklorz,Rosana; Sene,Fábio M..
Drosophila antonietae sp. nov. and D. gouveai sp. nov. are members of the D. buzzatii cluster of the D. repleta species group of the genus Drosophila. They can be distinguished from their cryptic species, D. borborema Vilela &amp; Sene, 1977, D. koepferae Fontdevila &amp; Wasserman, 1988, D. serido Vilela &amp; Sene, 1977, and D. seriema Tidon-Sklorz &amp; Sene, 1995 by morphological, genetic and ecological criteria.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Buzzatii cluster; Serido sibling set; Taxonomy; Neotropical.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0073-47212001000100014
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Seasonal dynamics of a drosophilid (Diptera) assemblage and its potencial as bioindicator in open environments Iheringia, Sér. Zool.
Bizzo,Luís; Gottschalk,Marco S; Toni,Daniela C. De; Hofmann,Paulo R. P.
Drosophila Fallen, 1823 (Diptera, Drosophilidae) is for long a well-established model organism for genetics and evolutionary research. The ecology of these flies, however, has only recently been better studied. Recent papers show that Drosophila assemblies can be used as bioindicators of forested environment degradation. In this work the bioindicator potential of drosophilids was evaluated in a naturally opened environment, a coastal strand-forest (restinga). Data from nine consecutive seasonal collections revealed strong temporal fluctuation pattern of the majority of Drosophila species groups. Drosophila willistoni group was more abundant at autumns, whereas D. cardini and D. tripunctata groups were, respectively, expressive at winters and springs, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Seasonality; Bioindicators; Restinga; Brazil.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0073-47212010000300001
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Temperature, urbanization and body color polymorphism in South Brazilian populations of Drosophila kikkawai (Diptera, Drosophilidae) Iheringia, Sér. Zool.
Costa,Bartira E. Pinheiro da; Rohde,Cláudia; Valente,Vera Lúcia da Silva.
Body color polymorphism of urban populations of cosmopolite fly Drosophila kikkawai Burla, 1954 was investigated in relation to its possible association with environmental temperature. Samples of D. kikkawai were collected in spring, summer, autumn and winter between 1987 to 1988, in zones with different levels of urbanization in the southern Brazilian city of Porto Alegre, Rio Grande do Sul. A clear association was observed between darker flies and both seasons with low temperatures and areas of low urbanization (where temperature is generally lower than in urbanized areas). Results of preliminary laboratory experiments involving six generations of flies grown in chambers at temperatures of 17º and 25ºC confirmed this tendency to a relationship between...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Urban populations; Color polymorphism; Temperature.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0073-47212003000400005
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Variation in synonymous codon use and DNA polymorphism within the Drosophila genome ArchiMer
Bierne, Nicolas; Eyre Walker, A.
A strong negative correlation between the rate of amino-acid substitution and codon usage bias in Drosophila has been attributed to interference between positive selection at nonsynonymous sites and weak selection on codon usage. To further explore this possibility we have investigated polymorphism and divergence at three kinds of sites: synonymous, nonsynonymous and intronic in relation to codon bias in D. melanogaster and D. simulans. We confirmed that protein evolution is one of the main explicative parameters for interlocus codon bias variation (r(2) similar to 40%). However, intron or synonymous diversities, which could have been expected to be good indicators of local interference [here defined as the additional increase of drift due to selection on...
Tipo: Text Palavras-chave: Substitution rate; Selective constraints; Linkage; Hill Robertson interference; GC content; Drosophila; Diversity; Codon usage.
Ano: 2006 URL: http://archimer.ifremer.fr/doc/2006/publication-4221.pdf
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