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	Provedor de dados BJPS (3) Anais da ABC (AABC) (1) BABT (1) BJMBR (1) Electron. J. Biotechnol. (1) International Journal of Morphology (1) Mais... Autor Vilos,Cristian (2) Acuña,Luis (1) Adibkia,Khosro (1) Agarwal,Vishnu (1) Almeida,C.P. (1) Alonso-Castro,Angel Josabad (1) Ayata,Neşe (1) Baracat,E.C. (1) Bucak,Seyda (1) Báez-García,José Eduardo (1) Cantín,Mario (1) Constandil,Luis (1) DIAS,CRISTINA J. (1) Elgueta,Samanta (1) Escobar-Fica,Jorge (1) FARDILHA,MARGARIDA (1) FAUSTINO,MARIA AMPARO F. (1) Fattahi,Ali (1) Freitas,F.R. (1) GAMELAS,SARA (1) Mais... Palavra-chave Drug delivery (8) Liposomes (2) PLGA (2) Polymeric microparticles (2) Bioresorbable polyurethanes (1) Breast cancer (1) Cancer (1) Ceftiofur (1) Cell culture (1) Chemotherapy (1) Doxil (1) Flutamide (1) Gold nanoparticles (1) Hydrocortisone (1) LDL receptor (1) LRP-1 receptor (1) LipoDox (1) Lipoproteins (1) Livestock breeding industry (1) Macrodiol. (1) Mais... Tipo do documento Info:eu-repo/semantics/article (6) Journal article (2) Ano 2020 (1) 2018 (2) 2017 (1) 2016 (1) 2012 (2) 2011 (1) Mais... País Brazil (6) Chile (2) Idioma Inglês (8)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 8 Primeira ... 1 ... Última Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections Electron. J. Biotechnol. Vilos,Cristian; Constandil,Luis; Herrera,Natalia; Solar,Paula; Escobar-Fica,Jorge; Velásquez,Luis Alberto. Background: The infectious diseases in the livestock breeding industry represent a significant drawback that generates substantial economic loss and have led to the indiscriminate use of antibiotics. The formulation of polymeric microparticles loaded with antibiotics for veterinary use can: reduce the number of required doses; protect the drug from inactivation; and maintain a sustained-release of the antibiotic drug at effective levels. Accomplishing all of these goals would have a significant economic and animal health impact on the livestock breeding industry. Results: In this work, we formulated ceftiofur-loaded PHBV microparticles (PHBV-CEF) with a spherical shape, a smooth surface and diameter sizes between 1.65 and 2.37 μm. The... Tipo: Journal article Palavras-chave: Ceftiofur; Drug delivery; Livestock breeding industry; PHBV; Polymeric microparticles. Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582012000400001 Morphometric and Histopathologic Changes in Skeletal Muscle Induced for Injectable PLGA Microparticles International Journal of Morphology Acuña,Luis; Suazo Galdames,Iván; Zavando,Daniela; Elgueta,Samanta; Velásquez,Luis; Vilos,Cristian; Cantín,Mario. The administration of microencapsulated drug in a matrix acid poly(lactic-co-glycolic acid) (PLGA) by intramuscular (IM) in humans has been approved by the FDA for various applications though it is not clear what effect they have on the morphological parameters of muscle tissue. The aim of this study was to analyze the morphological changes in the skeletal muscle tissue with their use. We used 12 adult female Sprague Dawley rats (Rattus novergicus) that were injected into their right gastrocnemius muscle belly with: sterile vehicle solution (G1, n = 4), 0.5 mg PLGA microparticle (G2, n = 4) and 0.75 mg PLGA microparticle (G3, n = 4), both dissolved in a sterile vehicle solution. At 14 days post injection the number and diameter of muscle fibers, the level... Tipo: Journal article Palavras-chave: Skeletal muscle; Drug delivery; Polymeric microparticles; PLGA. Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200016 An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy Anais da ABC (AABC) MESQUITA,MARIANA Q.; DIAS,CRISTINA J.; GAMELAS,SARA; FARDILHA,MARGARIDA; NEVES,MARIA G.P.M.S.; FAUSTINO,MARIA AMPARO F.. ABSTRACT Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment. Tipo: Info:eu-repo/semantics/article Palavras-chave: Photodynamic therapy; Drug delivery; Liposomes; Silica nanoparticles; Gold nanoparticles; Polymeric micelles. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301101 Liposome and Their Applications in Cancer Therapy BABT Pandey,Himanshu; Rani,Radha; Agarwal,Vishnu. ABSTRACT Liposomes, the vesicles of phospholipid bilayer, can encapsulate both hydrophilic and lipophilic drugs and protect them from degradation. Liposomes have been extensively studied and continue to create intense interest in research since their discovery in the mid-1960s. Since then, liposomes have been considered to be the most successful nanocarriers for drug deliver and have made their way to the market. Currently, a number of liposomal formulations are on the marker for cancer treatment and many more are in pipe line. This review discusses about the liposome components, methods of preparation, drug encapsulation mechanism and the potential therapeutic applications of liposomes in cancer therapy. Tipo: Info:eu-repo/semantics/article Palavras-chave: Liposomes; Drug delivery; Cancer; Doxil; LipoDox; Myocet. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100303 Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer BJMBR Pires,L.A.; Hegg,R.; Freitas,F.R.; Tavares,E.R.; Almeida,C.P.; Baracat,E.C.; Maranhão,R.C.. Low-density lipoprotein (LDL) receptors are overexpressed in most neoplastic cell lines and provide a mechanism for the internalization and concentration of drug-laden nanoemulsions that bind to these receptors. The aim of the present study was to determine whether the administration of standard chemotherapeutic schemes can alter the expression of LDL and LDL receptor-related protein 1 (LRP-1) receptors in breast carcinoma. Fragments of tumoral and normal breast tissue from 16 consecutive volunteer women with breast cancer in stage II or III were obtained from biopsies before the beginning of neoadjuvant chemotherapy and after chemotherapy, from fragments excised during mastectomy. Tissues were analyzed by immunohistochemistry for both receptors. Because... Tipo: Info:eu-repo/semantics/article Palavras-chave: Breast cancer; Lipoproteins; LDL receptor; LRP-1 receptor; Chemotherapy; Nanoemulsion; Drug delivery. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600012 Preparation and in vitro characterization of monoclonal antibody ranibizumab conjugated magnetic nanoparticles for ocular drug delivery BJPS Ayata,Neşe; Sezer,Ali Demir; Bucak,Seyda; Turanlı,Eda Tahir. Gold coated magnetite nanoparticles were prepared and coated with ranibizumab as an ocular drug delivery system. The surface morphologies of the nanoparticles were determined by Scanning Electron Microscopy (SEM). The size and surface charge were determined by using the dynamic light scattering (DLS) technique. Crystallographic properties of the gold coated Fe3O4 nanoparticles were recorded on X-ray diffractometer (XRD) the XRD pattern of nanoparticlees were shown to have uniqe Fe3O4 and gold peaks. Conjugation of ranibizumab onto nanoparticles was achieved using the physical adsorption method. The amount of ranibizumab on the surface of the nanoparticles was determined by thermogravimetric analysis (TGA). In the in vitro release studies performed using UV... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ranibizumab; Monoclonal antibody; Drug delivery; Magnetic nanoparticles; Cell culture. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100587 Hydrocortisone release from tablets based on bioresorbable poly(ether-ester-urethane)s BJPS Orozco-Castellanos,Luis Manuel; Marcos-Fernández,Angel; Alonso-Castro,Angel Josabad; González-García,Gerardo; Báez-García,José Eduardo; Rivera-Leyva,Julio Cesar; Zapata-Morales,Juan Ramón; Ruiz-Padilla,Alan Joel. Abstract Bioresorbable linear poly(ether-ester-urethane)s with different hydrophilic characteristics were synthesized from triblock copolymers of poly(ε-caprolactone)-poly(ethylene oxide)-poly(ε-caprolactone) (PCL-PEO) as macrodiols, and L-lysine diisocyanate (LDI) or hexamethylenediisocyanate (HDI) were used as the required diisocyanates. Macrodiols were obtained by ring-opening polymerization (ROP) of ε-caprolactone (CL). Polyurethanes were synthesized by the reaction of the triblock copolymers with LDI or HDI in solution using stannous 2-ethylhexanoate as catalyst. Polyurethane tablets were fabricated and investigated as prospective drug delivery systems. The effect of the PEO content on the polymers' performance as drug carriers was evaluated. It was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bioresorbable polyurethanes; Drug delivery; Hydrocortisone; Macrodiol.. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100629 Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide BJPS Fattahi,Ali; Ghiasi,Mansoureh; Mohammadi,Pardis; Hosseinzadeh,Leila; Adibkia,Khosro; Mohammadi,Ghobad. In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The structure of the synthesized polymers was confirmed by FTIR and 1H-NMR. Flutamide-loaded nanoparticles were prepared by quasi-emulsion solvent diffusion technique. The nanoparticles were evaluated for size, zeta potential, polydispersity index, drug crystallinity, loading efficiency, and release properties. Also, the physicochemical properties of the nanoparticles were analyzed using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry, and Powder... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanoparticle; PLGA; Flutamide; Prazosin; Prostate cancer; Drug delivery. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400609 Registros recuperados: 8 Primeira ... 1 ... Última

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