Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BABT (1) BJMBR (1) BJPS (1) Autor Araujo,P.S. de (1) Costa,M.H.B. (1) Faljoni-Alário,A. (1) Kantilal,Bhujbal Rohan (1) Mukund,Jagtap Yogesh (1) Quintilio,W. (1) Sant'Anna,O.A. (1) Sousa,Andreza de (1) Sousa,Edésia Martins Barros de (1) Sudhakar,Ranpise Nisharani (1) Mais... Palavra-chave Drug delivery system (3) Adjuvant (1) Cancer treatment (1) Emulsion solvent diffusion-evaporation method (1) Floating microspheres (1) Hydrophobic modification (1) Mesoporous materials (1) Protein stability (1) Release modifiers (1) SBA15 (1) Vaccine delivery system (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (1) Ano 2012 (1) 2005 (1) 2002 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Ordered mesoporous silica carrier system applied in nanobiothecnology BABT Sousa,Andreza de; Sousa,Edésia Martins Barros de. Ordered mesoporous materials like SBA15 possess a network of channels and pores of well-defined size in the nanoscale range (2-50 nm). This particular pore architecture makes them suitable candidates for hosting and delivery under appropriate conditions of a variety of molecules of pharmaceutical interest, including radiopharmaceuticals. The characteristics of SBA-15 prepared in different temperatures and the behavior of this system regarding microencapsulation of a model drug were investigated. The calcined samples were formed in 0.2 g disks and were soaked in a solution of atenolol used as a model drug. The modification of the aging temperature provoked changes in the structure of the pores, indicating the presence of microporosity and connections... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesoporous materials; Drug delivery system; Cancer treatment; SBA15. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700036 The use of protein structure/activity relationships in the rational design of stable particulate delivery systems BJMBR Costa,M.H.B.; Quintilio,W.; Sant'Anna,O.A.; Faljoni-Alário,A.; Araujo,P.S. de. The recombinant heat shock protein (18 kDa-hsp) from Mycobacterium leprae was studied as a T-epitope model for vaccine development. We present a structural analysis of the stability of recombinant 18 kDa-hsp during different processing steps. Circular dichroism and ELISA were used to monitor protein structure after thermal stress, lyophilization and chemical modification. We observed that the 18 kDa-hsp is extremely resistant to a wide range of temperatures (60% of activity is retained at 80ºC for 20 min). N-Acylation increased its ordered structure by 4% and decreased its ß-T1 structure by 2%. ELISA demonstrated that the native conformation of the 18 kDa-hsp was preserved after hydrophobic modification by acylation. The recombinant 18 kDa-hsp resists to a... Tipo: Info:eu-repo/semantics/other Palavras-chave: Protein stability; Hydrophobic modification; Vaccine delivery system; Drug delivery system; Adjuvant. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600014 Floating microspheres: a review BJPS Mukund,Jagtap Yogesh; Kantilal,Bhujbal Rohan; Sudhakar,Ranpise Nisharani. Gastric emptying is a complex process, one that is highly variable and that makes in vivo performance of drug delivery systems uncertain. A controlled drug delivery system with prolonged residence time in the stomach can be of great practical importance for drugs with an absorption window in the upper small intestine. The main limitations are attributed to the inter- and intra-subject variability of gastro-intestinal (GI) transit time and to the non-uniformity of drug absorption throughout the alimentary canal. Floating or hydrodynamically controlled drug delivery systems are useful in such applications. Various gastroretentive dosage forms are available, including tablets, capsules, pills, laminated films, floating microspheres, granules and powders.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Floating microspheres; Emulsion solvent diffusion-evaporation method; Drug delivery system; Release modifiers. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100003 Registros recuperados: 3 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco