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	Provedor de dados BJPS (1) Autor Ahmad,Mahmood (1) Khalid,Ikrima (1) Minhas,Muhammad Usman (1) Sohail,Muhammad (1) Palavra-chave Drugs/bioadhesion (1) Drugs/release profile (1) Flurbifrofen/mucoadhesive controlled release tablets/formulation (1) Flurbifrofen/mucoadhesive controlled release tablets/in vitroevaluation (1) Tablets/direct compression (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2014 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology BJPS Khalid,Ikrima; Ahmad,Mahmood; Minhas,Muhammad Usman; Sohail,Muhammad. The objective of the current study was to formulate mucoadhesive controlled release matrix tablets of flurbiprofen and to optimize its drug release profile and bioadhesion using response surface methodology. Tablets were prepared via a direct compression technique and evaluated for in vitro dissolution parameters and bioadhesive strength. A central composite design for two factors at five levels each was employed for the study. Carbopol 934 and sodium carboxymethylcellulose were taken as independent variables. Fourier transform infrared (FTIR) spectroscopy studies were performed to observe the stability of the drug during direct compression and to check for a drug-polymer interaction. Various kinetic models were applied to evaluate drug release from the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Flurbifrofen/mucoadhesive controlled release tablets/formulation; Flurbifrofen/mucoadhesive controlled release tablets/in vitroevaluation; Drugs/release profile; Drugs/bioadhesion; Tablets/direct compression. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300493 Registros recuperados: 1 Primeira ... 1 ... Última

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