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Novel ion exchange resin-based combination drug-delivery system for treatment of gastro esophageal reflux diseases BJPS
Bhalekar,Mangesh Ramesh; Kadam,Nitin Madhukar; Patil,Nilam Hindurao; Gawale,Nitin Somnath; Madgulkar,Ashwini.
The present study involves preparation and characterization of a combination tablet of ranitidine in immediate release form and domperidone in sustained release form, using ion exchange resins. Ranitidine lowers acid secretion, while domperidone release over a prolonged period improves gastric motility thus justifying this combination in gastro esophageal reflux diseases (GERD) and ensuring patient compliance. Drug loading was carried out by batch method & resinates were characterized using FTIR, XRPD. Resinates were formulated as a combination tablet and evaluated for tablet properties & in vitro drug release. Resinates provided sustained release of domperidone and immediate release of ranitidine. IR and X-ray studies indicate complexation...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/delivery system; Ranitidine/tablets; Ranitidine/immediate release; Domperidone/tablets; Domperidone/sustained release; Tablets/delivery system; Ion exchange resins/use; Ion exchange resins/drugs delivery system; Fármacos/sistema de liberação.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200021
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Mechanical properties and total hydroxycinnamic derivative release of starch/glycerol/Melissa officinalis extract films BJPS
Rechia,Letícia Mello; Morona,Juliana Bergman de Jesus; Zepon,Karine Modolon; Soldi,Valdir; Kanis,Luiz Alberto.
The aim of this study was to investigate the mechanical properties of starch/glycerol/Melissa officinalis, a topical drug delivery system for labial herpes treatment. Four films were prepared with different concentrations of starch, glycerol, and Melissa officinalis extract. The results revealed that increasing the glycerol concentration in the film reduced elasticity modulus and tensile strength, exhibiting a plasticizing effect. The increase in free volume resulted in increased release of hydroxycinnamic derivatives expressed as rosmarinic acid.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/delivery system; Glycerol; Melissa officinalis; Herpes/treatment; Polymeric film; Starch.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300012
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