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	Provedor de dados BJPS (2) Autor Andreazza,Itamar Francisco (2) Déo,Simone Cristina (1) Goebel,Karin (1) Possamai,João Carlos (1) Souza,Dayse Fernanda de (1) Palavra-chave Drugs/modified release (2) Coated pellets/dissolution profile (1) Coated pellets/evaluation (1) Extrusion- Spheronisation/pellets obtention (1) Mesalamine/evaluation (1) Mesalamine/modified release (1) Mesalazine (1) Minitablets coated/evaluation (1) Minitablets coated/modified release (1) Polyethylene oxide/drugs coating (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Development of mesalazine pellets coated with methacrylic-derived polymer BJPS Déo,Simone Cristina; Andreazza,Itamar Francisco; Possamai,João Carlos. Mesalazine (5-ASA) is the standard drug for the treatment of inflammatory bowel disease (IBD) due to its local effect on intestinal and colonic mucosa. The effective and safe treatment of this disease requires more efficient delivery of the active substance to its site of action. The focus of this study was the use of multiparticulate systems, a modified release form in which the drug is divided into several functional subunits of release in the form of granules or pellets. When these forms are administered, they are rapidly disintegrated, distributing their content throughout the gastrointestinal tract. The aim of this study was to develop and evaluate a multiparticulate system consisting of pellets coated with polymer for pH-dependent release, derived... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesalazine; Coated pellets/evaluation; Coated pellets/dissolution profile; Extrusion- Spheronisation/pellets obtention; Drugs/modified release. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100013 Development of enteric coated sustained release minitablets containing mesalamine BJPS Souza,Dayse Fernanda de; Goebel,Karin; Andreazza,Itamar Francisco. The aim of this study was to develop and evaluate a multiparticulate modified release system, composed of minitablets with a sustained release matrix system coated with a pH-dependent release polymer, using mesalamine as a model drug. Polyox® WSR 1105 was the polymer used in the matrix system and Eudragit® L30D55 was used as a pH-dependent polymer. The minitablets (with 20%, 30% or 40% Polyox® concentration) were prepared by dry granulation, which led to good quality minitablets. The developed minitablets were coated in a fluidized bed at 8% of the coating level. Dissolution studies were performed in media that simulated the gastrointestinal tract (pH 1.4, 6.0 and 7.2) and showed that formulations with higher Polyox® concentrations were capable of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesalamine/modified release; Mesalamine/evaluation; Minitablets coated/modified release; Minitablets coated/evaluation; Polyethylene oxide/drugs coating; Drugs/modified release. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300014 Registros recuperados: 2 Primeira ... 1 ... Última

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