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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor Cao,Xuebing (1) Del Bel,E.A. (1) Hou,Dongzhi (1) Li,Sai (1) Novaretti,N. (1) Padovan-Neto,F.E. (1) Ping,Qineng (1) Sun,Shengang (1) Tumas,V. (1) Wang,Lei (1) Xu,Yan (1) da-Silva,C.A. (1) Mais... Palavra-chave Dyskinesia (2) 7-Nitroindazole (1) DARPP-32 (1) DOPA priming (1) ERK1/2 (1) FosB/AFosB (1) L-DOPA (1) Levodopa liposomes (1) Nitric oxide (1) Nitric oxide synthase (1) Parkinson’s disease (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2016 (1) 2010 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats Biol. Res. Cao,Xuebing; Hou,Dongzhi; Wang,Lei; Li,Sai; Sun,Shengang; Ping,Qineng; Xu,Yan. BACKGROUND: Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery systems is being actively researched and reported in the literature RESULTS: In this study, we used chitosan-coated levodopa liposomes to investigate the behavioral character and the expression of phosphorylated extracellular signal-regulated kinase (ERK1/2), dopamine- and cAMP-regulated phos-phoprotein of 32 kDa (DARPP-32) and FosB/AFosB in striatum of rat model of levodopa-induced dyskinesia (LID). We found that scores of abnormal involuntary movement (AIM) decreased significantly in liposome group (P < 0.05), compared with levodopa group.... Tipo: Journal article Palavras-chave: Dyskinesia; Levodopa liposomes; ERK1/2; DARPP-32; FosB/AFosB. Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100032 Lack of tolerance for the anti-dyskinetic effects of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, in rats BJMBR Novaretti,N.; Padovan-Neto,F.E.; Tumas,V.; da-Silva,C.A.; Del Bel,E.A.. 7-Nitroindazole (7-NI) inhibits neuronal nitric oxide synthase in vivo and reduces l-DOPA-induced dyskinesias in a rat model of parkinsonism. The aim of the present study was to determine if the anti-dyskinetic effect of 7-NI was subject to tolerance after repeated treatment and if this drug could interfere with the priming effect of l-DOPA. Adult male Wistar rats (200-250 g) with unilateral depletion of dopamine in the substantia nigra compacta were treated with l-DOPA (30 mg/kg) for 34 days. On the 1st day, 6 rats received ip saline and 6 received ip 7-NI (30 mg/kg) before l-DOPA. From the 2nd to the 26th day, all rats received l-DOPA daily and, from the 27th to the 34th day, they also received 7-NI before l-DOPA. Animals were evaluated before the drug... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Nitric oxide synthase; Parkinson’s disease; L-DOPA; Dyskinesia; DOPA priming; 7-Nitroindazole. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100006 Registros recuperados: 2 Primeira ... 1 ... Última

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