|
|
| CARVALHO,F. F.; NENCIONI,A. L. A.; LEBRUN,I.; DORCE,V. A. C.; SANDOVAL,M. R. L.. |
| It has been previously shown that the crude venom of Tityus serrulatus can cause convulsions. This study was designed to investigate the neurotoxic effects of B, C, G, and K fractions isolated from this venom. Intravenous injection of these fractions in mice (0.6 - 6.0 mg/kg body weight) showed that the C fraction is a potent convulsant and G fraction decreased the threshold for tonic hand limb extension elicited by transauricular electroshock. Unilateral injection of B, C, and K fractions, but not G fraction, into the hippocampus of rats (0.6 - 6.0 µg) caused electroencephalographic alterations consisting of spikes and epileptic discharges that began in the hippocampus and evolved to the cortex. The following motor signs were observed: movements of facial... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Scorpion fractions; Electroshock; Seizure; Neurodegeneration; EEG record; Hippocampus; Tityus serrulatus. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302000000200008 |
| |
