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Is there an association between T102C polymorphism of the serotonin receptor 2A gene and urinary incontinence? BJMBR
Schwanke,C.H.A.; Bittencourt,L.; Noronha,J.A.P.; Augustin,S.A.J.; Jung,I.E.; Cruz,I.B.M..
The regulation of bladder function is influenced by central serotonergic modulation. Several genetic polymorphisms related to serotonin control have been described in the literature. T102C polymorphism of the serotonin receptor 2A gene (5-HT2A) has been shown to be associated with certain diseases such as non-fatal acute myocardial infarction, essential hypertension, and alcoholism. In the present study, we examined the association between 5-HT2A gene polymorphism and urinary incontinence in the elderly. A case-control study was performed in 298 elderly community dwellers enrolled in the Gravataí-GENESIS Project, Brazil, which studies gene-environmental interactions in aging and age-related diseases. Clinical, physical, biochemical, and molecular analyses...
Tipo: Info:eu-repo/semantics/article Palavras-chave: T102C polymorphism of the serotonin receptor 2A gene; 5-HT2A gene polymorphism; Urinary incontinence; Elderly patients.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001000003
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Acute myeloid leukemia in elderly patients: experience of a single center BJMBR
Rodrigues,C.A.; Chauffaille,M.L.L.F.; Pelloso,L.A.F.; Ghaname,F.S.; Kerbauy,D.M.B.; Campos,M.G.V.; Yamamoto,M..
Acute myeloid leukemia (AML) is a disease predominantly of older adults. Treatment of AML in the elderly is complicated not only by comorbidities but also by the high prevalence of poor prognosis markers. Thirty-one consecutive unselected patients with AML older than 60 years (representing 33% of all AML cases diagnosed at our institution during the same period) were followed over a period of 5 years (1997-2002). A high incidence of AML with multilineage dysplasia (45%) and no favorable cytogenetic abnormalities but 62% intermediate and 38% unfavorable karyotypes were found. Sixteen patients (52%) were selected for induction of intensive cytotoxic treatment and complete remission was achieved only by some of these intensively treated patients (7 of 16). Of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acute myeloid leukemia; Elderly patients; G-banding karyotype; Induction therapy; Overall survival.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000600004
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