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Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression BJMBR
Zhang,Xuezhi; Qin,Qiaoji; Dai,Hongyan; Cai,Shanglang; Zhou,Changyong; Guan,Jun.
Myocardial infarction (MI) is a common presentation for ischemic heart disease, which is a leading cause of death. Emodin is a Chinese herbal anthraquinone used in several diseases. However, the effect of emodin in hypoxia-induced injury in cardiomyocytes has not been clearly elucidated. Our study aimed to clarify the functions of emodin in hypoxia-induced injury in rat cardiomyocytes H9c2 and explore the underlying mechanism. The effects of emodin on cell viability and apoptosis were analyzed by the Cell counting kit-8 assay and flow cytometry assay, respectively. The cell proliferation- and cell apoptosis-related proteins were detected by western blot. qRT-PCR was used to determine the relative expression of miR-138. Cell transfection was performed to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Emodin; Myocardial infarction; Hypoxia injury; MiR-138; Sirt1/AKT pathway; Wnt/β-catenin pathway.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300603
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Polyphasic taxonomy of the heat resistant ascomycete genus Byssochlamys and its Paecilomyces anamorphs Naturalis
Samson, R.A.; Houbraken, J.; Varga, J.; Frisvad, J.C..
Byssochlamys and related Paecilomyces strains are often heat resistant and may produce mycotoxins in contaminated pasteurised foodstuffs. A comparative study of all Byssochlamys species was carried out using a polyphasic approach to find characters that differentiate species and to establish accurate data on potential mycotoxin production by each species. Phylogenetic analysis of the ITS region, parts of the â-tubulin and calmodulin genes, macro- and micromorphological examinations and analysis of extrolite profiles were applied. Phylogenetic analyses revealed that the genus Byssochlamys includes nine species, five of which form a teleomorph, i.e. B. fulva, B. lagunculariae, B. nivea, B. spectabilis and B. zollerniae, while four are asexual, namely P....
Tipo: Article / Letter to the editor Palavras-chave: Byssochlamys; Emodin; Eurotiales; Extrolites; Heat resistance; Mycophenolic acid; Paecilomyces; Patulin.
Ano: 2009 URL: http://www.repository.naturalis.nl/record/532420
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