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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor AVILA,ANA D (1) CALDERÓN,CARLOS F (1) Eguchi,S. (1) Inagami,T. (1) ORTIZ,ANA R (1) PEREDA,CELIA M (1) PEREZ,RITA M (1) PONS,CARMEN (1) Mais... Palavra-chave Epidermal growth factor receptor (2) Angiotensin II (1) Epidermal growth factor (1) Hemolytic toxins (1) Immunotoxins (1) Monoclonal antibodies (1) Type 1 receptor (1) Vascular smooth muscle cells (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2007 (1) 2000 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Construction of an immunotoxin by linking a monoclonal antibody against the human epidermal growth factor receptor and a hemolytic toxin Biol. Res. AVILA,ANA D; CALDERÓN,CARLOS F; PEREZ,RITA M; PONS,CARMEN; PEREDA,CELIA M; ORTIZ,ANA R. Hybrid molecules obtained through conjugation of monoclonal antibodies and toxins constitute an approach under exploration to generate potential agents for the treatment of cancer and other diseases. A frequently employed toxic component in the construction of such immunotoxins is ricin, a plant toxin which inhibits protein synthesis at ribosomal level and so requires to be internalized by the cell. A hemolytic toxin isolated from the sea anemone Stichodactyla helianthus, which is active at the cell membrane level, was linked through a disulfide bond to the anti-epidermal growth factor receptor monoclonal antibody ior egf/r3. The resulting immunotoxin did not exhibit hemolytic activity except under reducing conditions. It was toxic for H125 cells that... Tipo: Journal article Palavras-chave: Epidermal growth factor; Epidermal growth factor receptor; Hemolytic toxins; Immunotoxins; Monoclonal antibodies. Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200008 Angiotensin II-mediated vascular smooth muscle cell growth signaling BJMBR Inagami,T.; Eguchi,S.. The mechanism by which Ang II stimulates the growth of vascular smooth muscle cells was investigated by measuring the phosphorylation of mitogen-activated protein kinases ERK 1 and ERK 2. Ca2+ ionophore was found to have effects practically analogous to Ang II. We found that the signaling pathway involves the activation of epidermal growth factor receptor (EGFR) kinase, activation of the adaptor proteins Shc and Grb2, and the small G-protein Ras. Although the mechanism of AT1- (or Ca2+)-induced activation of EGFR is not yet clear, we have found that calcium-dependent protein kinase CAKß/PYK2 and c-Src are involved in this process. These studies indicate a transactivation mechanism that utilizes EGFR as a bridge between a Gq-coupled receptor and activation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin II; Type 1 receptor; Epidermal growth factor receptor; Vascular smooth muscle cells. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600002 Registros recuperados: 2 Primeira ... 1 ... Última

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