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	Provedor de dados BJPS (2) Autor Amin,Jinal (1) Chowdhury,Bikramaditya (1) Ghosal,Kajal (1) Maiti,Anindya Kishore (1) Nanda,Arunabha (1) Paradkar,Mansi (1) Rajabalaya,Rajan (1) Mais... Palavra-chave Ethyl cellulose (2) Eudragit S100 (1) Ex-vivo drug release study (1) Extrusion-spheronization (1) Glipizide/in-vitro release (1) Glipizide/physicochemical properties (1) Microcrystalline cellulose (1) Modified fluid bed coater (1) Plasticizer (1) Polyvinyl pyrrolidone (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Formulation development and evaluation of colon targeted delayed release methotrexate pellets for the treatment of colonic carcinoma BJPS Paradkar,Mansi; Amin,Jinal. Colonic carcinoma is one of the most common internal malignancies and is the second leading cause of deaths in United States. Methotrexate (MTX) is a drug of choice in the treatment of colon cancer. The aim of the present research work was to develop and characterize colon targeted pellets of MTX for treatment of colonic carcinoma. The product and process parameters were optimized by screening methods. Pellets were prepared by extrusion spheronization using microcrystalline cellulose (MCC) as spheronizing aid and ethyl cellulose (EC) as release retardant in different ratio. Based on the physical appearance, sphericity and % in vitro drug release, batch P17 containing EC: MCC (3:7) was optimized for core pellets. The site specificity was obtained by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ethyl cellulose; Microcrystalline cellulose; Eudragit S100; Extrusion-spheronization; Modified fluid bed coater; Ex-vivo drug release study. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400608 Evaluation of physicochemical properties and in-vitro release profile of glipizide-matrix patch BJPS Ghosal,Kajal; Rajabalaya,Rajan; Maiti,Anindya Kishore; Chowdhury,Bikramaditya; Nanda,Arunabha. OBJECTIVES: The aim of the present investigation was to form matrix patches with ethyl cellulose (EC) as the base polymer, polyvinyl pyrrolidone (PVP) as the copolymer, plasticizer with dibutyl phthalate (DBP) or acetyl tributyl citrate (ATBC) and the drug glipizide (gz) by the solvent casting method. Physicochemical properties of the patches and in vitro drug release were determined in a modified Keshary-chien diffusion cell to optimize the patch formulations with the help of experimental data and figures for further studies. TECHNIQUES: EC and PVP of different proportions with different weight percentages of either DBP or ATBC and a fixed amount of glipizide were taken for matrix patch formations. The dried patches were used for measuring their drug... Tipo: Info:eu-repo/semantics/article Palavras-chave: Glipizide/physicochemical properties; Glipizide/in-vitro release; Ethyl cellulose; Polyvinyl pyrrolidone; Plasticizer. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200007 Registros recuperados: 2 Primeira ... 1 ... Última

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