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	Provedor de dados BJPS (1) Autor Aragão,Cícero Flávio Soares (1) Freire,Fátima Duarte (1) Goes,Janaina da Silva (1) Moura,Túlio Flávio Accioly de Lima e (1) Raffin,Fernanda Nervo (1) Palavra-chave Captopril/ pharmacokinetics (1) Degradation Kinetics (1) Dosage Forms (1) Drug Compounding/ utilization (1) Drug Dosage Calculations (1) Drug Stability (1) Drug Utilization (1) Enzyme Stability/drug effects (1) Excipients/ pharmacokinetics (1) Kinetics (1) Pediatric Formulation (1) Thermal Analysis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2019 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies BJPS Goes,Janaina da Silva; Freire,Fátima Duarte; Moura,Túlio Flávio Accioly de Lima e; Aragão,Cícero Flávio Soares; Raffin,Fernanda Nervo. Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it undergoes oxidation producing captopril disulfide (its main metabolite). The aim of this formulation study was to suggest favorable conditions for the development of a stable captopril formulation. The compatibility between the drug and excipients was evaluated by differential scanning calorimetry analysis (DSC). For studies in solution, different formulations were prepared according to a factorial design varying EDTA concentration, water purity and pH. The resultant formulations were stored at 60°C and analyzed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pediatric Formulation; Captopril/ pharmacokinetics; Thermal Analysis; Degradation Kinetics; Drug Stability; Drug Compounding/ utilization; Drug Utilization; Excipients/ pharmacokinetics; Dosage Forms; Drug Dosage Calculations; Kinetics; Enzyme Stability/drug effects. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100603 Registros recuperados: 1 Primeira ... 1 ... Última

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