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Contrasting the crospovidones functionality as excipients for direct compression BJPS
Ramírez,Daniel García; Robles,Leopoldo Villafuerte.
Specific values of technological properties of excipients allow the establishment of numerical parameters to define and compare their functionality. This study investigates the functionality of Polyplasdones XL and XL10. Parameters studied included tablet disintegration profiles, compactibility profiles and powder flow. The results allowed the establishment of quantitative surrogate functionalities of technological performance, such as absolute number, and as a value relative to the known microcrystalline cellulose type 102. Moreover, the establishment of an explicit functionality to improve the technological performance of two diluents and a model drug was investigated, as was setting up of these functionalities, as quantitative values, to determine the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Excipients/functionality; Polyplasdones XL/functionality; Polyplasdones XL10/functionality; Tablets/compactibility; Tablets/disintegration time; Tablets/powder flow; Amoxicillin; Magnesium stearate; Superdisintegrants.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100155
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Functionality of innovative and generic celluloses in metronidazole formulations BJPS
Díaz Ramírez,Carmen Cristina; Villafuerte Robles,Leopoldo.
The wide variety of excipients available calls for evaluation of their functionality, in this case of the pharmaceutical performance of microcrystalline celluloses and sodium cross-linked carboxymethylcelluloses from different sources. This evaluation includes parameters such as powder flow, compactibility, ejection pressure and dissolution from fast-release tablets as well as from floating granules and controlled-release tablets. In a previous study, the excipient Carmacel® presented better disintegration properties compared to Croscarmellose®. However, the evaluation showed better compactibility performance for Croscarmellose®. These characteristics were observed using pure excipients. Nevertheless, these advantages have not been confirmed in tests...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Excipients/functionality; Microcrystalline celluloses; Sodium cross-linked carboxymethylcelluloses; Croscarmellose; Carmacel; Avicel; Alfacel; Tablets/disintegrants; Pharmaceutical dosage/forms.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100006
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