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Protective effect of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia BJMBR
Arruzazabala,M.L.; Noa,M.; Menéndez,R.; Más,R.; Carbajal,D.; Valdés,S.; Molina,V..
Policosanol is a mixture of higher aliphatic alcohols purified from sugar cane wax, with cholesterol-lowering effects demonstrable in experimental models and in patients with type II hypercholesterolemia. The protective effects of policosanol on atherosclerotic lesions experimentally induced by lipofundin in rabbits and rats and spontaneously developed in stumptail monkeys have been described. The present study was conducted to determine whether policosanol administered orally to rabbits with exogenous hypercholesterolemia also protects against the development of atherosclerotic lesions. Male New Zealand rabbits weighing 1.5 to 2 kg were randomly divided into three experimental groups which received 25 or 200 mg/kg policosanol (N = 7) orally for 60 days...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Policosanol; Atherosclerotic lesions; Exogenous hypercholesterolemia; Rabbits.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700015
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