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	Provedor de dados BJPS (1) Autor Amin,Jinal (1) Paradkar,Mansi (1) Palavra-chave Ethyl cellulose (1) Eudragit S100 (1) Ex-vivo drug release study (1) Extrusion-spheronization (1) Microcrystalline cellulose (1) Modified fluid bed coater (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Formulation development and evaluation of colon targeted delayed release methotrexate pellets for the treatment of colonic carcinoma BJPS Paradkar,Mansi; Amin,Jinal. Colonic carcinoma is one of the most common internal malignancies and is the second leading cause of deaths in United States. Methotrexate (MTX) is a drug of choice in the treatment of colon cancer. The aim of the present research work was to develop and characterize colon targeted pellets of MTX for treatment of colonic carcinoma. The product and process parameters were optimized by screening methods. Pellets were prepared by extrusion spheronization using microcrystalline cellulose (MCC) as spheronizing aid and ethyl cellulose (EC) as release retardant in different ratio. Based on the physical appearance, sphericity and % in vitro drug release, batch P17 containing EC: MCC (3:7) was optimized for core pellets. The site specificity was obtained by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ethyl cellulose; Microcrystalline cellulose; Eudragit S100; Extrusion-spheronization; Modified fluid bed coater; Ex-vivo drug release study. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400608 Registros recuperados: 1 Primeira ... 1 ... Última

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