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| RECABARREN,SERGIO E; LOBOS,ALEJANDRO; FIGUEROA,YARA; PADMANABHAN,VASANTHA; FOSTER,DOUGLAS L; SIR-PETERMANN,TERESA. |
| Although evidence is accumulating that prenatal testosterone (T) compromises reproductive function in the female, the effects of excess T in utero on the postnatal development of male reproductive function has not been studied. The aim of this study was to assess the influence of prenatal T excess on age-related changes in pituitary and gonadal responsiveness to GnRH in the male sheep. We used the GnRH agonist, leuprolide (10 µg/kg), as a pharmacologic challenge at 5, 10, 20 and 30 weeks of age. These time points correspond to early and late juvenile periods and the prepubertal and postpubertal periods of sexual development, respectively. LH and T were measured in blood samples collected before and after GnRH agonist administration. The area under the... |
| Tipo: Journal article |
Palavras-chave: Fetal programming; IUGR; Pituitary sensitivity. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000400007 |
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| RECABARREN,SERGIO E; SIR-PETERMANN,TERESA; LOBOS,ALEJANDRO; CODNER,ETHEL; ROJAS-GARCÍA,PEDRO P; REYES,VÍCTOR. |
| Similar to women with Polycystic Ovary Syndrome (PCOS), female sheep treated prenatally with testosterone (T-females) are hypergonadotropic, exhibit neuroendocrine defects, multifollicular ovarian morphology, hyperinsulinemia and cycle defects. Hypergonadotropism and multifollicular morphology may in part be due to developmentally regulated increase in pituitary responsiveness to GnRH and may culminate in increased ovarian estradiol production. In this study, we utilized a GnRH agonist, leuprolide, to determine the developmental impact of prenatal testosterone exposure on pituitary-gonadal function and to establish if prenatal exposure produces changes in the reproductive axis similar to those described for women with PCOS. Eight control and eight... |
| Tipo: Journal article |
Palavras-chave: Androgenized females; Fetal programming; PCOS; Leuprolide; Female sheep. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200013 |
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| Pinheiro,D.F.; Pacheco,P.D.G.; Alvarenga,P.V.; Buratini Jr,J.; Castilho,A.C.S.; Lima,P.F.; Sartori,D.R.S.; Vicentini-Paulino,M.L.M.. |
| This study investigated the consequences of intrauterine protein restriction on the gastrointestinal tract and particularly on the gene expression and activity of intestinal disaccharidases in the adult offspring. Wistar rat dams were fed isocaloric diets containing 6% protein (restricted, n = 8) or 17% protein (control, n = 8) throughout gestation. Male offspring (n = 5-8 in each group) were evaluated at 3 or 16 weeks of age. Maternal protein restriction during pregnancy produced offspring with growth restriction from birth (5.7 ± 0.1 vs 6.3 ± 0.1 g; mean ± SE) to weaning (42.4 ± 1.3 vs 49.1 ± 1.6 g), although at 16 weeks of age their body weight was similar to control (421.7 ± 8.9 and 428.5 ± 8.5 g). Maternal protein restriction also increased lactase... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MRNA enzyme abundance; Maternal protein restriction; Disaccharidase activity; Fetal programming. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300287 |
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