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| Burbano,R.R.; Lima,E.M.; Khayat,A.S.; Barbieri Neto,J.; Cabral,I.R.; Bastos Jr.,L.; Bahia,M.O.; Casartelli,C.. |
| Twelve breast fibroadenomas were analyzed cytogenetically and only four were found to have clonal alterations. The presence of chromosomal alterations in fibroadenomas must be the consequence of the proliferating process and must not be related to the etiology of this type of lesion. In contrast, the few fibroadenomas that exhibit chromosomal alterations are likely to be those presenting a risk of neoplastic transformation. Clonal numerical alterations involved chromosomes 8, 18, 19, and 21. Of the chromosomal alterations found in the present study, only monosomy of chromosomes 19 and 21 has been reported in breast fibroadenomas. The loss of chromosome 21 was the most frequent alteration found in our sample. The study of benign proliferations and their... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Fibroadenomas; Chromosome alterations; Breast cancer. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000800005 |
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