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| NAEEM,MUHAMMAD; RAHMAN,NISAR UR; TAVARES,GUILHERME. D.; BARBOSA,SÁVIO F.; CHACRA,NÁDIA B.; LÖBENBERG,RAIMAR; SARFRAZ,MUHAMMAD K.. |
| ABSTRACTFlurbiprofen, a potent nonsteroidal anti-inflammatory drug, is widely used for relief of pain in patients suffering from rheumatic diseases, migraine, sore throat and primary dysmenorrheal. However, this drug has many gastrointestinal side effects produced by its oral administration, such as gastric bleeding and peptic ulcer. These effects were responsible for non-compliance among patients, which ultimately results in treatment failure. The physicochemical properties of flurbiprofen, make it a suitable candidate for transdermal drug delivery, which can overcome the drawbacks of oral administration. In this sense, microemulsions have been proved to increase the cutaneous absorption of lipophilic drugs when compared to conventional drug delivery... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anti-inflammatory study; Flurbiprofen; Gels; In vitro permeation; Microemulsion. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000401823 |
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| Tilkan,Müşerref Günseli Yüksel; Özdemir,Nurten. |
| ABSTRACT Flurbiprofen (FLB), a NSAID, widely used for preventing pain generally for arthritis or dental problems. In this study, FLB loaded chitosan microspheres were prepared by ionotropic gelation method. In this method, microspheres were formed by dropping chitosan solutions containing FLB into sodium alginate solutions including sodium tripolyphosphate (TPP). A variety of formulation parameters like drug:polymer ratio, drug concentration, polymer’s molecular weight, polymer concentration, pH and the concentration of TPP solutions, drying method and stirring time were analyzed. The dissolution studies were performed in a shaking water bath in pH 7.4 phosphate buffer saline (PBS) at 37 °C. Laser diffractometer was used for particle size analysis, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Flurbiprofen; Chitosan; Tripolyphosphate; Ionotropic gelation; Microsphere. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400621 |
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