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The quality control of glycoprotein folding in the endoplasmic reticulum, a trip from trypanosomes to mammals BJMBR
Parodi,A.J..
The present review deals with the stages of synthesis and processing of asparagine-linked oligosaccharides occurring in the lumen of the endoplasmic reticulum and their relationship to the acquisition by glycoproteins of their proper tertiary structures. Special emphasis is placed on reactions taking place in trypanosomatid protozoa since their study has allowed the detection of the transient glucosylation of glycoproteins catalyzed by UDP-Glc:glycoprotein glucosyltransferase and glucosidase II. The former enzyme has the unique property of covalently tagging improperly folded conformations by catalyzing the formation of protein-linked Glc1Man7GlcNAc2, Glc1Man8GlcNac2 and Glc1Man9GlcNAc2 from the unglucosylated proteins. Glucosyltransferase is a soluble...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycoproteins; N-glycosylation; Folding; Endoplasmic reticulum; Glucosylation.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000500002
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Insights into the role of hydration in protein structure and stability obtained through hydrostatic pressure studies BJMBR
Royer,C.A..
A thorough understanding of protein structure and stability requires that we elucidate the molecular basis for the effects of both temperature and pressure on protein conformational transitions. While temperature effects are relatively well understood and the change in heat capacity upon unfolding has been reasonably well parameterized, the state of understanding of pressure effects is much less advanced. Ultimately, a quantitative parameterization of the volume changes (at the basis of pressure effects) accompanying protein conformational transitions will be required. The present report introduces a qualitative hypothesis based on available model compound data for the molecular basis of volume change upon protein unfolding and its dependence on temperature.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pressure perturbation calorimetry; Folding; Thermal expansivity; Volume change.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000800003
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Recent and active deformation pattern off the easternmost Algerian margin, Western Mediterranean Sea: New evidence for contractional tectonic reactivation ArchiMer
Kherroubi, Abdelaziz; Deverchere, Jacques; Yelles, Abdelkarim; De Lepinay, Bernard Mercier; Domzig, Anne; Cattaneo, Antonio; Bracene, Rabah; Gaullier, Virginie; Graindorge, David.
We describe for the first time a set of large active thrusts and folds near the foot of the easternmost Algerian margin, Western Mediterranean, from swath bathymetry and high-resolution seismic data acquired in 2005 during the Maradja2/Samra cruise. This active system resumes a previous passive margin and creates growth strata deposition on the limbs of large folds, resulting in the development of perched basins at the foot of the margin since less than similar to 1 Ma. They form a set of overlapping fault segments verging toward the Algerian basin, in a way similar to what has been observed off eastern Algiers on the rupture zone of the 2003 Mw 6.8 Boumerdes earthquake. The horizontal shortening rate across large folds is estimated to be of the order of 1...
Tipo: Text Palavras-chave: Subduction inception; Africa Eurasia convergence; Seismic reflection; Seismic hazards; Growth strata; Folding; Active faulting; Annaba; Algerian margin.
Ano: 2009 URL: http://archimer.ifremer.fr/doc/2009/publication-6850.pdf
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Speaking Stata: Graphs for all seasons AgEcon
Cox, Nicholas J..
Time series showing seasonality—marked variation with time of year—are of interest to many scientists, including climatologists, other environmental scientists, epidemiologists, and economists. The usual graphs plotting response variables against time, or even time of year, are not always the most effective at showing the fine structure of seasonality. I survey various modifications of the usual graphs and other kinds of graphs with a range of examples. Although I introduce here two new Stata commands, cycleplot and sliceplot, I emphasize exploiting standard functions, data management commands, and graph options to get the graphs desired.
Tipo: Journal Article Palavras-chave: Cycleplot; Sliceplot; Seasonality; Time series; Graphics; Cycle plot; Rotation; State space; Incidence plots; Folding; Repeating; Research Methods/ Statistical Methods.
Ano: 2006 URL: http://purl.umn.edu/117590
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