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	Provedor de dados Ciênc. Tecnol. Aliment. (1) Autor LEW,Sze-Yuen (1) LIM,Lee-Wei (1) WONG,Kah-Hui (1) YOW,Yoon-Yen (1) Palavra-chave Antioxidant (1) Dermal fibroblasts (1) Friedreich’s ataxia (1) Hericium erinaceus (1) Oxidative damage (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2019 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Antioxidant-mediated protective role of Hericium erinaceus (Bull.: Fr.) Pers. against oxidative damage in fibroblasts from Friedreich’s ataxia patient Ciênc. Tecnol. Aliment. LEW,Sze-Yuen; YOW,Yoon-Yen; LIM,Lee-Wei; WONG,Kah-Hui. Abstract Friedreich’s ataxia (FRDA) is a progressive neuromuscular disorder caused by substantial decrease of mitochondrial protein frataxin responsible for biogenesis of iron-sulphur clusters and protection from oxidative damage. In this study, we investigated the antioxidant activities of a standardized aqueous extract from fruiting bodies of Hericium erinaceus mushroom (HESAE) and its protective effects against oxidative damage induced by L-Buthionine sulfoximine (BSO) in fibroblasts derived from FRDA patient. The lactate dehydrogenase-based viability assay showed that FRDA fibroblast was sensitive to 12.5 mM BSO with a reduction of viability to 52.51 ± 13.92% after 24 h of BSO exposure. Interestingly, co-incubation with 32 mg/mL HESAE increased the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hericium erinaceus; Friedreich’s ataxia; Dermal fibroblasts; Antioxidant; Oxidative damage. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612019005000306 Registros recuperados: 1 Primeira ... 1 ... Última

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