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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor He,Xingxing (1) Jiang,Tao (1) Li,Shusheng (1) Si,Liangyi (1) Wang,Min (1) Yan,Jingjun (1) Zhan,Chengye (1) Zhong,Qiang (1) Mais... Palavra-chave Functional enrichment analysis (2) Acute respiratory distress syndrome (1) Aortic dissection (1) Differentially expressed genes (1) Differentially expressed mRNAs (1) MicroRNAs (1) Pathway analysis (1) Protein-protein interaction network (1) Sepsis (1) Small molecules (1) Transcription factors (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2019 (1) 2016 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile Biol. Res. Wang,Min; Yan,Jingjun; He,Xingxing; Zhong,Qiang; Zhan,Chengye; Li,Shusheng. BACKGROUND: Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the years, the absence of a universal detail disease mechanism up until now has led to a series of practical problems for a definitive treatment. This study aimed to predict some genes or pathways associated with sepsis-related ARDS based on a public microarray dataset and to further explore the molecular mechanism of ARDS RESULTS: A total of 122 up-regulated DEGs and 91 down-regulated differentially expressed genes (DEGs) were obtained. The up- and down-regulated... Tipo: Journal article Palavras-chave: Acute respiratory distress syndrome; Sepsis; Differentially expressed mRNAs; Functional enrichment analysis; Pathway analysis; Transcription factors. Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100025 Identification of the molecular mechanisms associated with acute type A aortic dissection through bioinformatics methods BJMBR Jiang,Tao; Si,Liangyi. Aortic dissection is characterized by the redirection of blood flow, which flows through an intimal tear into the aortic media. The purpose of this study was to find potential acute type A aortic dissection (AAAD)-related genes and molecular mechanisms by bioinformatics. The gene expression profiles of GSE52093 were obtained from Gene Expression Omnibus (GEO) database, including 7 AAAD samples and 5 normal samples. The differentially expressed genes (DEGs) were detected between AAAD and normal samples. The functional annotation and pathway enrichment analysis were conducted through the Database for Annotation, Visualization and Integration Discovery (DAVID). A protein-protein interaction network was established by the Search Tool for the Retrieval of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aortic dissection; Differentially expressed genes; Functional enrichment analysis; Protein-protein interaction network; MicroRNAs; Small molecules. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001100610 Registros recuperados: 2 Primeira ... 1 ... Última

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