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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor Beirão,P.S.L. (1) Cruz,J.S. (1) Mudado,M.A. (1) Prado,V.F. (1) Rodrigues,A.L. (1) STOJILKOVIC,STANKO S (1) Mais... Palavra-chave GH3 cells (2) Action potentials (1) BK channels (1) Calcium channel (1) Electrophysiology (1) Exocytosis (1) Gonadotrophs (1) Lactotrophs (1) RT-PCR (1) SK channels (1) Somatotrophs (1) T-type (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2006 (1) 2004 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Pituitary cell type-specific electrical activity, calcium signaling and secretion Biol. Res. STOJILKOVIC,STANKO S. All secretory anterior pituitary cells exhibit spontaneous and extracellular calcium-dependent electrical activity, but differ with respect to the patterns of firing and associated calcium signaling and hormone secretion. Thus, somatotrophs and lactotrophs fire plateau-bursting action potentials spontaneously and without coupling to calcium release from intracellular stores, which generate calcium signals of sufficient amplitude to keep steady hormone release. In these cells, both spontaneous electrical activity and basal hormone secretion can be further amplified by activation of Gq/11 and Gs-coupled receptors and inhibited by Gi/o/z-coupled receptors. In contrast, gonadotrophs fire single, high-amplitude spikes with limited ability to promote calcium... Tipo: Journal article Palavras-chave: Somatotrophs; Lactotrophs; Gonadotrophs; GH3 cells; SK channels; BK channels; Action potentials; Exocytosis. Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300004 CaV 3.1 and CaV 3.3 account for T-type Ca2+ current in GH3 cells BJMBR Mudado,M.A.; Rodrigues,A.L.; Prado,V.F.; Beirão,P.S.L.; Cruz,J.S.. T-type Ca2+ channels are important for cell signaling by a variety of cells. We report here the electrophysiological and molecular characteristics of the whole-cell Ca2+ current in GH3 clonal pituitary cells. The current inactivation at 0 mV was described by a single exponential function with a time constant of 18.32 ± 1.87 ms (N = 16). The I-V relationship measured with Ca2+ as a charge carrier was shifted to the left when we applied a conditioning pre-pulse of up to -120 mV, indicating that a low voltage-activated current may be present in GH3 cells. Transient currents were first activated at -50 mV and peaked around -20 mV. The half-maximal voltage activation and the slope factors for the two conditions are -35.02 ± 2.4 and 6.7 ± 0.3 mV (pre-pulse of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Calcium channel; T-type; Electrophysiology; RT-PCR; GH3 cells. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600020 Registros recuperados: 2 Primeira ... 1 ... Última

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