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Role of CD4⁺ T Cells in the Control of Primary Infection with Babesia microti in Mice OAK
Igarashi, Ikuo; Waki, Seiji; Ito, Mamoru; Omata, Yoshitaka; Saito, Atsushi; Suzuki, Naoyoshi; 五十嵐, 郁男.
Palavras-chave: Babesia microti; Nude mice; CD4⁺ T Cells; Primary infection; Gamma interferon.
Ano: 1994 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/218
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Interleukin-15 as a potential regulator of the innate immune response BJMBR
Carson,W.; Caligiuri,M.A..
Interleukin-15 (IL-15) is a newly-discovered cytokine that is produced by activated monocytes early in the course of the innate immune response. IL-15 is able to bind to components of the interleukin-2 receptor (IL-2R) despite the fact that it has no sequence homology with IL-2. IL-15 stimulates human natural killer cell proliferation, cytotoxicity, and cytokine production and can substitute for IL-2 under most conditions. In vitro studies indicate that monocyte-derived IL-15 may be an important determinant of IFN-gamma production by NK cells. In addition, IL-15 is able to promote the survival of natural killer cells under serum-free conditions. The IL-15 receptor is a heterotrimeric complex which is composed of the IL-2Rß and <FONT...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Interleukin-15; Interleukin-12; Gamma interferon; Natural killer cell; Innate immunity.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100001
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