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Serum metabolic profiling of human gastric cancer based on gas chromatography/mass spectrometry BJMBR
Song,Hu; Peng,Jun-Sheng; Dong-Sheng,Yao; Yang,Zu-Li; Liu,Huan-Liang; Zeng,Yi-Ke; Shi,Xian-Ping; Lu,Bi-Yan.
Research on molecular mechanisms of carcinogenesis plays an important role in diagnosing and treating gastric cancer. Metabolic profiling may offer the opportunity to understand the molecular mechanism of carcinogenesis and help to non-invasively identify the potential biomarkers for the early diagnosis of human gastric cancer. The aims of this study were to explore the underlying metabolic mechanisms of gastric cancer and to identify biomarkers associated with morbidity. Gas chromatography/mass spectrometry (GC/MS) was used to analyze the serum metabolites of 30 Chinese gastric cancer patients and 30 healthy controls. Diagnostic models for gastric cancer were constructed using orthogonal partial least squares discriminant analysis (OPLS-DA). Acquired...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Metabolomics; Gastric cancer; Gas chromatography/mass spectrometry.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100013
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Volatile compounds from organic and conventional passion fruit (Passiflora edulis F. Flavicarpa) pulp Ciênc. Tecnol. Aliment.
Macoris,Mariana Serrão; Janzantti,Natália Soares; Garruti,Deborah dos Santos; Monteiro,Magali.
The volatile compositions from organic and conventional passion fruit pulps produced in Brazil were investigated. The pulps were also physicochemically characterized. The volatile compounds from the headspace of the passion fruit pulp were stripped to a Porapak Q trap for 2 hours; they were eluted with 300 µL of dichloromethane, separated by gas chromatography/flame ionisation detection and identified through gas chromatography/mass spectrometry. Both pulps conformed to the requirements of the Brazilian legislation, indicating they were suitable to be industrialized and consumed. A total of 77 compounds were detected in the headspace of the passion fruit pulps - 60 of which were identified, comprising 91% of the total chromatogram area. The major compounds...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Organic passion fruit; Aroma; Flavor chemistry; Fruit pulp; Gas chromatography/mass spectrometry.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612011000200023
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