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| Rodrigues,Patrícia A.; Morais,Selene M.; Souza,Carolina M.; Magalhães,Davi V.; Vieira,Ícaro G.P.; Andrade,Geanne M.; Rao,Vietla S.; Santos,Flávia A.. |
| Byrsonima sericea leaves are extensively used in folk medicine in Brazil against gastric disorders. This study investigated the chemical constituents of B. sericea leaf ethanolic extract (BSLE) and its potential gastroprotective activity, with its possible mechanism of the action using ethanol to induce gastric mucosal damage in mice. The phytochemical analysis was carried out to identify the active constituents present in the extract, and the HPLC analysis was performed for the identification of flavonoids. BSLE at oral doses of 125, 250 and 500 mg/kg markedly attenuated the ethanol-evoked gastric lesions by 53.2, 84.9 and 87.6 %, respectively. The BSLE (250 mg/kg) prevented the depletion of gastric mucus and gastric mucosal nonproteic-sulfhydryl groups,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidant; Byrsonima sericea; Flavonoids; Gastroprotection; Mechanisms of action. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000100011 |
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| SILVA,DAYANE M.; MARTINS,JOSÉ L.R.; FLORENTINO,IZIARA F.; OLIVEIRA,DANILLO R.; FAJEMIROYE,JAMES O.; TRESNVENZOL,LEONICE M.F.; PAULA,JOSÉ R.; COSTA,ELSON A.. |
| ABSTRACT Memora nodosa is popularly known as "caroba" and widely found in the Cerrado regions of Brazil. In traditional medicine, the leaves and stems are used for the healing of external ulcer and the roots for abdominal pain. This study investigated the effect of ethanolic roots extract of Memora nodosa (EMN) on the gastric mucosa of mice. In the indomethacin induced gastric ulcer model, the treatments of the animals with EMN at doses of 100, 300 and 1000 mg/kg, p.o., markedly reduced the index of lesions. In the gastric ulcer models induced by ethanol and cold restraint-stress the previous treatment with EMN at dose of 300 mg/kg showed 69% and 43% of protection, respectively. Seven days after food-restriction, the animals treated with EMN (300 mg/kg... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gastric lesion; Gastroprotection; Medicinal plants; Memora nodosa; Mucus; Traditional medicine. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501819 |
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| Fernandes,Hélio B; Silva,Francilene V; Passos,Flávia Franceli B; Bezerra,Roosevelt D S; Chaves,Mariana H; Oliveira,Francisco A; Meneses Oliveira,Rita C. |
| Parkia platycephala Benth. (Leguminosae - Mimosoideae), popularly known as "visgueira", fava bean tree or "fava-de-bolota", is widely found in the Northern and Northeastern regions of Brazil. Its pods are used as cattle food supplement in the drought period. Compounds with a gastroprotective activity were obtained from the genus Parkia. Therefore, this study aimed at investigating the gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves (Pp-EtOH), as well as evaluating its possible mechanisms of action in experimental ulcer induction models. Lesions were induced by absolute ethanol, ethanol-HCl, ischemia-reperfusion and indomethacin in rodents. Pp-EtOH showed a protective effect in the lesion models (66, 48 and 52 %,... |
| Tipo: Journal article |
Palavras-chave: Antioxidant; Ethanol; Gastroprotection; Nitric oxide; Parkia platycephala; Ulcer. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400010 |
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